Kuriyama H, Osa T, Toida N
J Physiol. 1967 Jul;191(2):239-55. doi: 10.1113/jphysiol.1967.sp008248.
The membrane properties of single cells of intestinal smooth muscle of duodenum, jejunum, ileum, caecum and rectum of guinea-pig have been studied.1. The membrane potentials of longitudinal muscles of the duodenum, jejunum, ileum, caecum and rectum varied from 54 to 56 mV and those of circular muscles of jejunum, ileum, caecum and rectum varied from 57 to 60 mV. The ablated longitudinal muscle had a slightly lower value (50 mV) than the intact one.2. The longitudinal muscle generated spontaneous discharges but these were rare in the circular muscles of the intestine except for the caecum. Overshoot potentials could be observed in all regions of the intestine. The maximum rate of rise of the spontaneously discharging longitudinal muscles varied from 11 to 18 V/sec.3. Not all of the slow potential changes (but at least some) were generated by the nervous elements distributed between the muscle layers and in them.4. The conduction velocities measured from the longitudinal muscles of jejunum and rectum in the presence of tetrodotoxin were 2.1 cm/sec and 4.0 cm/sec respectively.5. Chronaxies of the longitudinal muscles of jejunum and rectum were 2-5 msec and 5-18 msec respectively.6. Intracellular stimulation of the single cells of the duodenum and caecum could trigger a spike, similar to that observed in the taenia coli. The spikes were mostly graded ones; a spike of full size was rarely elicited. When the spikes were triggered, the after-hyperpolarization appeared consistently presumably caused by the increased potassium conductance.7. The effective membrane resistance and the time constant were measured for the longitudinal muscles of the jejunum and rectum. When spikes were generated by intracellular stimulation the observed values were 40-50 MOmega and 3-5 msec in both tissues. These values were the same as those observed in the taenia coli.8. When the time constant of the membrane was measured by the extracellular polarizing method, the longitudinal muscles of the jejunum especially and the rectum had smaller time constants than the taenia coli.9. The differences of conduction velocity and chronaxie of the different regions of the intestine are discussed in relation to the cable properties of the tissues which are directly influenced by the morphological arrangements of the tissues.
对豚鼠十二指肠、空肠、回肠、盲肠和直肠的肠平滑肌单细胞的膜特性进行了研究。
十二指肠、空肠、回肠、盲肠和直肠纵肌的膜电位在54至56mV之间变化，空肠、回肠、盲肠和直肠环肌的膜电位在57至60mV之间变化。切除后的纵肌值（50mV）略低于完整纵肌。
纵肌产生自发放电，但除盲肠外，肠环肌中这种放电很少见。在肠道的所有区域都可观察到超射电位。自发放电纵肌的最大上升速率在11至18V/秒之间变化。
并非所有的慢电位变化（但至少有一些）都是由分布在肌层之间及其内部的神经成分产生的。
在存在河豚毒素的情况下，从空肠和直肠纵肌测得的传导速度分别为2.1cm/秒和4.0cm/秒。
空肠和直肠纵肌的时值分别为2 - 5毫秒和5 - 18毫秒。
对十二指肠和盲肠的单细胞进行细胞内刺激可引发一个峰电位，类似于在结肠带中观察到的情况。这些峰电位大多是分级的；很少引发全尺寸的峰电位。当引发峰电位时，后超极化始终出现，推测是由钾电导增加引起的。
测量了空肠和直肠纵肌的有效膜电阻和时间常数。当通过细胞内刺激产生峰电位时，在这两种组织中观察到的值分别为40 - 50MΩ和3 - 5毫秒。这些值与在结肠带中观察到的值相同。
当通过细胞外极化方法测量膜的时间常数时，特别是空肠纵肌和直肠的时间常数比结肠带小。
讨论了肠道不同区域传导速度和时值的差异与组织的电缆特性的关系，而组织的电缆特性直接受组织形态排列的影响。
