Ekenved G, Magnusson A, Bodemar G, Walan A
Scand J Gastroenterol. 1977;12(8):963-6. doi: 10.3109/00365527709181357.
The absorption of a quartenary (propantheline, 30 mg) and a tetiary (1-hyoscyamine, 0.8 mg) anticholinergic compound was studied in 8 healthy volunteers by measuring the effects on salivation. Both compounds were administered as rapidly disintegrating tablets, 1-hyoscyamine also in a slow-release formulation (Egazil Durules). The three preparations and placebo were administered under fasting conditions and with a standardized light meal using a randomized cross-over design. Salivation measurement were performed with a citric acid stimulation method every hour for 10 hours. In the fasting patient, all three anticholinergic test preparations decreased the salivation significantly. When taken with food, the effect of propantheline was almost abolished, while the effects of the 1-hyoscyamine preparations were uninfluenced. It was concluded that the clinical effects of proprantheline might be extremely varying depending how the drug is taken in relation to meals. In contrast the clinical effects of 1-hyoscyamine seem to be independent of food intake.
通过测量对唾液分泌的影响，在8名健康志愿者中研究了一种季铵类（丙胺太林，30毫克）和一种叔胺类（消旋莨菪碱，0.8毫克）抗胆碱能化合物的吸收情况。两种化合物均以速崩片形式给药，消旋莨菪碱也有缓释制剂（埃加齐尔长效片）。三种制剂和安慰剂在禁食条件下以及在食用标准化便餐时采用随机交叉设计给药。使用柠檬酸刺激法每小时进行一次唾液分泌测量，共测量10小时。在禁食患者中，所有三种抗胆碱能试验制剂均显著减少唾液分泌。与食物一起服用时，丙胺太林的作用几乎消失，而消旋莨菪碱制剂的作用不受影响。得出的结论是，丙胺太林的临床效果可能因服药与进餐的关系而有极大差异。相比之下，消旋莨菪碱的临床效果似乎与食物摄入无关。
