Vejlsted H, Hansen M, Jacobsen E
Acta Anaesthesiol Scand. 1977;21(6):529-33. doi: 10.1111/j.1399-6576.1977.tb01256.x.
In order to investigate the duration of respiratory depression following neurolept anaesthesia, 21 patients who had hemilaminectomia performed were subjected to ventilation-carbon dioxide response tests by a rebreathing method in the post-operative period. Up to 3 1/2 h after start of anaesthesia all patients had a decreased ventilatory response to carbon dioxide. After this period some patients showed a normal respiratory response, while others remained depressed for up to 6 h, the period for which the investigation lasted. Most patients in the depressed group were premedicated with pethidine. We conclude that additional narcotics are contraindicated for a period of 3 1/2 h following the start of neurolept anaesthesia for surgical procedures lasting 1-2 h, while clinical control is still necessary before administration of additional narcotics within 6 h, especially if narcotics have been used as premedication.
为了研究神经安定麻醉后呼吸抑制的持续时间，对21例行半椎板切除术的患者在术后采用再呼吸法进行通气-二氧化碳反应试验。麻醉开始后长达3.5小时，所有患者对二氧化碳的通气反应均降低。在此之后，一些患者显示出正常的呼吸反应，而另一些患者在长达6小时的研究期间仍处于呼吸抑制状态，研究持续此时间段。呼吸抑制组中的大多数患者术前使用了哌替啶。我们得出结论，对于持续1-2小时的外科手术，在神经安定麻醉开始后3.5小时内禁忌使用额外的麻醉剂，而在6小时内使用额外麻醉剂之前仍需临床控制，尤其是在术前已使用麻醉剂的情况下。
