Léjohn H B, Van Caeseele L, Lees H
J Bacteriol. 1967 Nov;94(5):1484-91. doi: 10.1128/jb.94.5.1484-1491.1967.
Several fermentable carbon sources were found to give rise to catabolite repression of all enzymes implicated in thiosulfate oxidation in the facultative chemoautotroph, Thiobacillus novellus. Glucose was found to elicit a strong repression. Glycerol, lactate, lactose, ribose, and pyruvate caused marked repression. In all cases, the repression could be relieved only by returning the cells to a medium devoid of such fermentable substrates. On the other hand, carbon compounds (amino acids and organic acids) that are metabolizable only aerobically caused transient or no repression of the thiosulfate oxidative system. All of the enzymes believed to participate in thiosulfate oxidation, except tetrathionase, were found to be simultaneously induced and repressed. This would suggest that tetrathionate may not be a necessary intermediate in the thiosulfate-oxidation pathway of T. novellus.
已发现几种可发酵碳源会导致兼性化能自养菌——新型硫杆菌中所有参与硫代硫酸盐氧化的酶受到分解代谢阻遏。葡萄糖会引发强烈的阻遏作用。甘油、乳酸、乳糖、核糖和丙酮酸会导致明显的阻遏。在所有情况下，只有将细胞重新接种到不含此类可发酵底物的培养基中，阻遏作用才能解除。另一方面，仅需有氧代谢的碳化合物（氨基酸和有机酸）会导致硫代硫酸盐氧化系统产生短暂阻遏或无阻遏作用。除连四硫酸盐酶外，所有被认为参与硫代硫酸盐氧化的酶均被发现会同时被诱导和阻遏。这表明连四硫酸盐可能不是新型硫杆菌硫代硫酸盐氧化途径中的必要中间体。
