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5-羟色胺对贻贝平滑肌的作用。

The action of 5-hydroxytryptamine on Mytilus smooth muscle.

作者信息

Hidaka T, Osa T, Twarog B M

出版信息

J Physiol. 1967 Oct;192(3):869-77. doi: 10.1113/jphysiol.1967.sp008337.

DOI:10.1113/jphysiol.1967.sp008337
PMID:6059006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1365548/
Abstract
  1. In the nerve-muscle preparation, where catch was characteristically minimal, 5-hydroxytryptamine (5-HT) had no effect on resting membrane potential, junction potentials, spikes or contraction.2. In muscle bundles, where catch was prominent, 5-HT did not change membrane potentials, but prolonged junction potentials and lowered the threshold for spike discharge and contraction.3. In muscle bundles, exposed to high concentrations of 5-HT, depolarization evoked repetitive spikes, while in low 5-HT, spikes were seldom fired even with much greater depolarization.4. In muscle bundles, the effective membrane resistance, R(eff.), decreased from 45-60 to 23-35 MOmega as 5-HT concentration was increased.5. It is suggested that 5-HT may facilitate spike discharge by lowering the internal free Ca(2+) concentration.
摘要

  1. 在神经 - 肌肉标本中，强直特性通常很微弱，5 - 羟色胺（5 - HT）对静息膜电位、接头电位、锋电位或收缩均无影响。

  2. 在强直现象明显的肌束中，5 - HT不改变膜电位，但延长接头电位并降低锋电位发放和收缩的阈值。

  3. 在暴露于高浓度5 - HT的肌束中，去极化诱发重复锋电位，而在低浓度5 - HT时，即使去极化程度更大也很少发放锋电位。

  4. 在肌束中，随着5 - HT浓度增加，有效膜电阻R(eff.)从45 - 60兆欧降至23 - 35兆欧。

  5. 提示5 - HT可能通过降低细胞内游离Ca(2+)浓度促进锋电位发放。

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The action of 5-hydroxytryptamine on Mytilus smooth muscle.5-羟色胺对贻贝平滑肌的作用。
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本文引用的文献

1
The relation between the mechanical and electrical activity of a molluscan unstriated muscle.软体动物平滑肌的机械活动与电活动之间的关系。
J Physiol. 1937 Nov 26;91(2):172-85. doi: 10.1113/jphysiol.1937.sp003550.
2
The nature of the phasic and the tonic responses of the anterior byssal retractor muscle of Mytilus.贻贝前足丝牵缩肌的相位和紧张性反应的性质。
J Physiol. 1959 Dec;149(1):154-77. doi: 10.1113/jphysiol.1959.sp006332.
3
The fate of 5-hydroxytryptamine in a smooth muscle and in connective tissue.5-羟色胺在平滑肌和结缔组织中的命运。
J Physiol. 1962 Apr;161(1):160-74. doi: 10.1113/jphysiol.1962.sp006879.
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The pharmacology of a molluscan smooth muscle.软体动物平滑肌的药理学。
Br J Pharmacol Chemother. 1959 Sep;14(3):404-7. doi: 10.1111/j.1476-5381.1959.tb00266.x.
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Innervation and activity of a molluscan smooth muscle.一种软体动物平滑肌的神经支配与活动
J Physiol. 1960 Jul;152(2):220-35. doi: 10.1113/jphysiol.1960.sp006483.
6
Effects of acetylcholine and 5-hydroxytryptamine on the contraction of a molluscan smooth muscle.乙酰胆碱和5-羟色胺对软体动物平滑肌收缩的影响。
J Physiol. 1960 Jul;152(2):236-42. doi: 10.1113/jphysiol.1960.sp006484.
7
A pharmacological analysis of the contractile mechanism of Mytilus muscle.贻贝肌肉收缩机制的药理学分析。
J Physiol. 1959 Oct;148(3):451-64. doi: 10.1113/jphysiol.1959.sp006299.
8
The quantitative distribution of 5-hydroxytryptamine in the invertebrates, especially in their nervous systems.5-羟色胺在无脊椎动物中的定量分布，尤其是在其神经系统中的分布。
J Neurochem. 1960 Sep;6:146-69. doi: 10.1111/j.1471-4159.1960.tb13460.x.
9
Electrochemical aspects of physiological and pharmacological action in excitable cells. II. The action potential and excitation.可兴奋细胞生理和药理作用的电化学方面。II. 动作电位与兴奋
Pharmacol Rev. 1958 Jun;10(2):165-273.
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Observations on the distribution of amine oxidase in invertebrates.关于胺氧化酶在无脊椎动物中分布的观察
Arch Biochem Biophys. 1957 Jul;69:10-5. doi: 10.1016/0003-9861(57)90465-4.