5-羟色胺对贻贝平滑肌的作用。
The action of 5-hydroxytryptamine on Mytilus smooth muscle.
作者信息
Hidaka T, Osa T, Twarog B M
出版信息
J Physiol. 1967 Oct;192(3):869-77. doi: 10.1113/jphysiol.1967.sp008337.
Abstract
- In the nerve-muscle preparation, where catch was characteristically minimal, 5-hydroxytryptamine (5-HT) had no effect on resting membrane potential, junction potentials, spikes or contraction.2. In muscle bundles, where catch was prominent, 5-HT did not change membrane potentials, but prolonged junction potentials and lowered the threshold for spike discharge and contraction.3. In muscle bundles, exposed to high concentrations of 5-HT, depolarization evoked repetitive spikes, while in low 5-HT, spikes were seldom fired even with much greater depolarization.4. In muscle bundles, the effective membrane resistance, R(eff.), decreased from 45-60 to 23-35 MOmega as 5-HT concentration was increased.5. It is suggested that 5-HT may facilitate spike discharge by lowering the internal free Ca(2+) concentration.
摘要
在神经 - 肌肉标本中，强直特性通常很微弱，5 - 羟色胺（5 - HT）对静息膜电位、接头电位、锋电位或收缩均无影响。
在强直现象明显的肌束中，5 - HT不改变膜电位，但延长接头电位并降低锋电位发放和收缩的阈值。
在暴露于高浓度5 - HT的肌束中，去极化诱发重复锋电位，而在低浓度5 - HT时，即使去极化程度更大也很少发放锋电位。
在肌束中，随着5 - HT浓度增加，有效膜电阻R(eff.)从45 - 60兆欧降至23 - 35兆欧。
提示5 - HT可能通过降低细胞内游离Ca(2+)浓度促进锋电位发放。
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