Kerboeuf D
Ann Rech Vet. 1977;8(3):257-66.
To determine the relationship between the course of infection by parasites of the genus Haemoncus and variations in the level of serum pepsinogen, an experiment was done with three groups of five lambs. The first was a non-infested control group. The lambs of the second group were given one dose of 10,000 H. contortus infective larvae. The animals of the third group were given one dose of 50,000 larvae. Fluctuations of the level of serum pepsinogen were determined throughout the experimental period (88 days). Observations also included variations of protein and lipid levels. Our experimental results showed that the development of H. contortus larvae, even when in small numbers, can cause lesions comparable to ostertagiosis in abomasum and produce the same rise in the level of serum pepsinogen. This increase in serum pepsinogen appeared to be related to the amount of larvae which were given. The high level of serum pepsinogen persisted over a long period. Variations of the serum, total protein and albumin levels were the same as described by other authors. There was no decrease in serum lipids.
为了确定血矛线虫属寄生虫的感染过程与血清胃蛋白酶原水平变化之间的关系，对三组每组五只羔羊进行了实验。第一组为未感染的对照组。第二组羔羊接种一剂10,000条捻转血矛线虫感染性幼虫。第三组动物接种一剂50,000条幼虫。在整个实验期（88天）内测定血清胃蛋白酶原水平的波动情况。观察内容还包括蛋白质和脂质水平的变化。我们的实验结果表明，即使少量的捻转血矛线虫幼虫发育，也可引起与真胃奥斯特他线虫病相当的病变，并使血清胃蛋白酶原水平出现相同程度的升高。血清胃蛋白酶原的这种升高似乎与接种的幼虫数量有关。血清胃蛋白酶原的高水平持续了很长时间。血清、总蛋白和白蛋白水平的变化与其他作者所描述的相同。血清脂质没有下降。
