Hartmann A, Schütz H J, Alberti E, Schreckenberger F, Loew D, Dýcka J
Arch Psychiatr Nervenkr (1970). 1977 Dec 28;224(4):351-60. doi: 10.1007/BF00341617.
The effect of a new, powerful diuretic on biochemical parameters, urine output, central venous pressure, blood pressure, and cerebrospinal fluid pressure in patients with supratentorial intracerebral tumors who showed signs and symptoms of increased intracranial pressure was tested. When compared to an untreated control group and to the steady-state data of each patient, CSF pressure was significantly reduced using a dose of 240 mg of the diuretic. The 120 mg dosage did not produce significant results. Normalization of increased cerebrospinal fluid pressure was not completely obtained using either dose. Used alone, this substance is not suitable for treatment of increased intracranial pressure due to brain edema in patients with intra-cerebral tumors. It might, however, be useful in combination with other medications.
测试了一种新型强效利尿剂对幕上脑肿瘤且有颅内压升高体征和症状患者的生化指标、尿量、中心静脉压、血压及脑脊液压力的影响。与未治疗的对照组及每位患者的稳态数据相比，使用240mg剂量的利尿剂时脑脊液压力显著降低。120mg剂量未产生显著效果。两种剂量均未完全实现脑脊液压力升高的正常化。单独使用时，该物质不适用于治疗脑肿瘤患者因脑水肿导致的颅内压升高。然而，它可能与其他药物联合使用时有用。
