己烯雌酚和酚酞的某些阴离子衍生物在豚鼠体内的胆汁排泄
Biliary excretion of some anionic derivatives of diethylstilboestrol and phenolphthalein in the guinea pig.
作者信息
Barford P A, Olavesen A H, Curtis C G, Powell G M
出版信息
Biochem J. 1977 Dec 15;168(3):373-7. doi: 10.1042/bj1680373.
The metabolic fates and modes of excretion of diethylstilboestrol mono[35S]sulphate and diethylstilboestrol di[35S]sulphate were studied in the guinea pig. Comparative studies were also made with [G-3H]diethylstilboestrol and phenolphthalein di[35S]sulphate. Diethylstiboesterol di[35S]sulphate was extensively eliminated in the bile unchanged. After administration of diethylstilboestrol mono[35S]sulphate, extensive biliary elimination of radioactivity was also recorded. Radioactive components were identified as diethylstilboestrol disulphate, diethylstilboestrol monosulphate monoglucuronide and unchanged diethylstilboestrol monosulphate. When [G-3H]diethylstilboestrol was administered, 3H-labelled diethylstilboestrol monoglucuronide, diethylstilboestrol monosulphate monoglucuronide and diethylstilboestrol disulphate appeared in the bile. Phenolphthalein di[35S]sulphate was excreted unchanged in bile. These findings are discussed in relation to studies carried out in the rat [Barford, Olavesen, Curtis & Powell (1977) Biochem. J. 164, 423--430] and species differences are related to differences in enzyme activities in rat and guinea-pig liver.
在豚鼠体内研究了硫酸二乙己烯雌酚单[35S]酯和硫酸二乙己烯雌酚二[35S]酯的代谢归宿及排泄方式。还对[G-3H]二乙己烯雌酚和酚酞二[35S]硫酸盐进行了比较研究。硫酸二乙己烯雌酚二[35S]酯在胆汁中大量以原形排出。给予硫酸二乙己烯雌酚单[35S]酯后，也记录到放射性物质在胆汁中的大量排泄。放射性成分被鉴定为硫酸二乙己烯雌酚、硫酸二乙己烯雌酚单葡萄糖醛酸酯和未变化的硫酸二乙己烯雌酚单酯。给予[G-3H]二乙己烯雌酚时，3H标记的二乙己烯雌酚单葡萄糖醛酸酯、硫酸二乙己烯雌酚单葡萄糖醛酸酯和硫酸二乙己烯雌酚二酯出现在胆汁中。酚酞二[35S]硫酸盐在胆汁中以原形排泄。结合在大鼠身上进行的研究[Barford, Olavesen, Curtis & Powell (1977) Biochem. J. 164, 423 - 430]对这些发现进行了讨论，物种差异与大鼠和豚鼠肝脏中酶活性的差异有关。
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