红细胞膜中胆固醇的跨膜迁移（“翻转”）
Transmembrane migration ('flip-flop') of cholesterol in erythrocyte membranes.
作者信息
Kirby C, Green C
出版信息
Biochem J. 1977 Dec 15;168(3):575-7. doi: 10.1042/bj1680575.
Abstract
After exchange with [14C]cholesterol-labelled plasma lipoproteins for 0.5-4h, erythrocytes were extracted with bile-salt solutions. The extracted cholesterol (mainly from the outside of the erythrocyte membrane) had the same specific radioactivity as the residual sterol. Thus cholesterol equilibrates rapidly (half-time less than 1 h) between the two sides of the membrane.
摘要
在用[14C]胆固醇标记的血浆脂蛋白进行0.5 - 4小时的交换后，用胆盐溶液提取红细胞。提取出的胆固醇（主要来自红细胞膜的外侧）与残留固醇具有相同的比放射性。因此，胆固醇在膜的两侧之间迅速达到平衡（半衰期小于1小时）。
相似文献
1
Transmembrane migration ('flip-flop') of cholesterol in erythrocyte membranes.红细胞膜中胆固醇的跨膜迁移（“翻转”）
Biochem J. 1977 Dec 15;168(3):575-7. doi: 10.1042/bj1680575.
2
The rate of transmembrane movement of cholesterol in the human erythrocyte.人类红细胞中胆固醇的跨膜移动速率。
J Biol Chem. 1981 Jun 10;256(11):5321-3.
3
Validation of an in vitro method for incorporating labelled cholesterol into human erythrocytes.
Prep Biochem. 1979;9(3):247-59. doi: 10.1080/00327487908061689.
4
Transmembrane movement of cholesterol in human erythrocytes.胆固醇在人红细胞中的跨膜转运
Proc Natl Acad Sci U S A. 1977 Apr;74(4):1538-42. doi: 10.1073/pnas.74.4.1538.
5
The effect in vitro of ionizing irradiation and small rises in temperature on the uptake and release of labelled lipids by the human erythrocyte membrane.电离辐射和温度小幅升高对人红细胞膜摄取和释放标记脂质的体外影响。
Biochim Biophys Acta. 1978 Feb 27;528(2):230-8. doi: 10.1016/0005-2760(78)90197-2.
6
7
The exchangeability of human erythrocyte membrane cholesterol.
J Supramol Struct. 1978;8(4):391-7. doi: 10.1002/jss.400080402.
8
9
[Effect of the plasma lipoprotein spectrum on the cholesterol level in erythrocyte membranes].[血浆脂蛋白谱对红细胞膜胆固醇水平的影响]
Vopr Med Khim. 1985 Jul-Aug;31(4):83-7.
10
Effects of cholesterol on transmembrane water diffusion in human erythrocytes measured using pulsed field gradient NMR.使用脉冲场梯度核磁共振测量胆固醇对人红细胞跨膜水扩散的影响。
Biophys Chem. 1995 Aug;55(3):197-208. doi: 10.1016/0301-4622(95)00007-k.
引用本文的文献
1
Influenza viral membrane fusion is sensitive to sterol concentration but surprisingly robust to sterol chemical identity.流感病毒膜融合对固醇浓度敏感，但对固醇化学特性出人意料地稳健。
Sci Rep. 2016 Jul 19;6:29842. doi: 10.1038/srep29842.
2
Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement.动物真核细胞膜中的磷脂：横向不对称性与运动
Biochem J. 1993 Aug 15;294 ( Pt 1)(Pt 1):1-14. doi: 10.1042/bj2940001.
3
Lipid vesicle-mediated alterations of membrane cholesterol levels: effects on Na+ and K+ currents in squid axon.脂质囊泡介导的膜胆固醇水平改变：对鱿鱼轴突中Na+和K+电流的影响。
J Membr Biol. 1981;63(3):191-8. doi: 10.1007/BF01870980.
4
ACTH stimulation on cholesterol side chain cleavage activity of adrenocortical mitochondria. Transfer of the stimulus from plasma membrane to mitochondria.促肾上腺皮质激素对肾上腺皮质线粒体胆固醇侧链裂解活性的刺激作用。刺激从质膜向线粒体的传递。
Mol Cell Biochem. 1981 Apr 27;36(2):105-22. doi: 10.1007/BF02354909.
5
Transmembrane movements of lipids.脂质的跨膜运动
Experientia. 1990 Jun 15;46(6):644-56. doi: 10.1007/BF01939703.
本文引用的文献
1
Cholesterol metabolism in the macrophage. I. The regulation of cholesterol exchange.巨噬细胞中的胆固醇代谢。I. 胆固醇交换的调节。
J Exp Med. 1971 Dec 1;134(6):1545-69. doi: 10.1084/jem.134.6.1545.
2
Incorporation of lipid vesicles by mammalian cells provides a potential method for modifying cell behaviour.哺乳动物细胞摄取脂质囊泡为改变细胞行为提供了一种潜在方法。
Nature. 1974 Nov 8;252(5479):163-6. doi: 10.1038/252163a0.
3
The rate of cholesterol 'flip-flop' in lipid bilayers and its relation to membrane sterol pools.
FEBS Lett. 1974 May 15;42(1):108-11. doi: 10.1016/0014-5793(74)80291-7.
4
The properties of mitochondria enriched in vitro with cholesterol.体外富含胆固醇的线粒体的特性。
Eur J Biochem. 1970 Jan;12(1):58-66. doi: 10.1111/j.1432-1033.1970.tb00820.x.
5
The release of membrane components prior to haemolysis during extraction of intact eryghrocytes with bile salts.
Biochim Biophys Acta. 1976 Apr 5;426(4):776-80. doi: 10.1016/0005-2736(76)90146-2.
6
Asymmetry and transposition rates of phosphatidylcholine in rat erythrocyte ghosts.大鼠红细胞膜空壳中磷脂酰胆碱的不对称性及转位率
Biochemistry. 1976 Mar 23;15(6):1277-83. doi: 10.1021/bi00651a017.
7
Transbilayer movement of cholesterol in dipalmitoyllecithin-cholesterol vesicles.胆固醇在二棕榈酰卵磷脂 - 胆固醇囊泡中的跨膜运动。
Nature. 1976 Feb 5;259(5542):420-1. doi: 10.1038/259420a0.
8
Topological asymmetry of phospholipid metabolism in rat erythrocyte membranes. Evidence for flip-flop of lecithin.大鼠红细胞膜中磷脂代谢的拓扑不对称性。卵磷脂翻转的证据。
Eur J Biochem. 1976 Jan 2;61(1):53-8. doi: 10.1111/j.1432-1033.1976.tb09996.x.
9
Transbilayer distribution and movement of cholesterol and phospholipid in the membrane of influenza virus.胆固醇和磷脂在流感病毒膜中的跨膜分布与运动
Proc Natl Acad Sci U S A. 1976 Feb;73(2):391-5. doi: 10.1073/pnas.73.2.391.
10
Analysis of membrane halves: cholesterol.膜片分析：胆固醇。
Proc Natl Acad Sci U S A. 1976 Jan;73(1):173-7. doi: 10.1073/pnas.73.1.173.
Zotero 插件