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亚甲蓝对兔红细胞中谷氨酸和还原型谷胱甘肽的影响。

Effect of Methylene Blue on glutamate and reduced glutathione of rabbit erythrocytes.

作者信息

Smith J E, Mahaffey E, Lee M

出版信息

Biochem J. 1977 Dec 15;168(3):587-9. doi: 10.1042/bj1680587.

DOI:10.1042/bj1680587
PMID:606257
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1183811/
Abstract

Methylene Blue injected into rabbits resulted in increased glutamate, reduced glutathione and pyrrolid-2-one-5-carboxylate in erythrocytes. The increase in reduced glutathione was probably due to increased glutamate changing the feedback control of glutathione on gamma-glutamylcysteine synthetase.

摘要

向兔子体内注射亚甲蓝会导致红细胞中谷氨酸增加、谷胱甘肽减少以及吡咯烷-2-酮-5-羧酸盐减少。还原型谷胱甘肽的增加可能是由于谷氨酸增加改变了谷胱甘肽对γ-谷氨酰半胱氨酸合成酶的反馈控制。

相似文献

1
Effect of Methylene Blue on glutamate and reduced glutathione of rabbit erythrocytes.亚甲蓝对兔红细胞中谷氨酸和还原型谷胱甘肽的影响。
Biochem J. 1977 Dec 15;168(3):587-9. doi: 10.1042/bj1680587.
2
Formation of 5-oxoproline from glutathione in erythrocytes by the gamma-glutamyltranspeptidase-cyclotransferase pathway.通过γ-谷氨酰转肽酶-环转移酶途径，红细胞中的谷胱甘肽形成5-氧代脯氨酸。
Proc Natl Acad Sci U S A. 1974 Feb;71(2):293-7. doi: 10.1073/pnas.71.2.293.
3
The effect of methylene blue and diaminodiphenysulfone on red cell reduced glutathione synthesis.亚甲蓝和二氨基二苯砜对红细胞还原型谷胱甘肽合成的影响。
J Lab Clin Med. 1972 Oct;80(4):481-7.
4
Porphobilinogen synthetase activity response to increased levels of reduced glutathione produced by methylene blue, in blood, liver and kidney.血、肝和肾中胆色素原合成酶活性对亚甲蓝产生的还原型谷胱甘肽水平升高的反应。
Biomedicine. 1979 Sep;31(5):132-5.
5
Methylene blue directly oxidizes glutathione without the intermediate formation of hydrogen peroxide.亚甲蓝直接氧化谷胱甘肽，不会中间形成过氧化氢。
J Biol Chem. 1985 Dec 5;260(28):15168-71.
6
Interactions between methylene blue and erythrocytes of several mammalian species, in vitro.
Proc Soc Exp Biol Med. 1974 Oct;147(1):245-9. doi: 10.3181/00379727-147-38319.
7
Oxidation of glutathione by methylene blue is equivalent in G-6-PD deficient and normal erythrocytes.在葡萄糖-6-磷酸脱氢酶（G-6-PD）缺乏的红细胞和正常红细胞中，亚甲蓝对谷胱甘肽的氧化作用是相同的。
Res Commun Chem Pathol Pharmacol. 1986 May;52(2):265-8.
8
[Research in vivo on the action of methylene blue on erythrocytes].[亚甲蓝对红细胞作用的体内研究]
Boll Soc Ital Biol Sper. 1965 Sep 30;41(18):1046-9.
9
[The behavior of reduced glutathione (GSH) in erythrocytes during Heinz body formation].[海因茨小体形成过程中红细胞内还原型谷胱甘肽（GSH）的行为]
Folia Haematol Int Mag Klin Morphol Blutforsch. 1962;78:676-81.
10
Methylene blue and erythrocytes in the living animal. Contribution to the toxicology of methylene blue and formation of Heinz bodies.活体动物体内的亚甲蓝与红细胞。对亚甲蓝毒理学及海因茨小体形成的贡献。
Toxicol Appl Pharmacol. 1967 Jul;11(1):81-7. doi: 10.1016/0041-008x(67)90029-4.

本文引用的文献

1
DETERMINATION OF CYSTEINE.
Anal Biochem. 1963 Dec;6:486-90. doi: 10.1016/0003-2697(63)90141-6.
2
UTILIZATION OF ALPHA-KETOGLUTARATE BY RED BLOOD CELLS FOR GLUTATHIONE SYNTHESIS.红细胞利用α-酮戊二酸进行谷胱甘肽合成
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Glutathione biosynthesis in human erythrocytes. I. Identification of the enzymes of glutathione synthesis in hemolysates.人类红细胞中的谷胱甘肽生物合成。I. 溶血产物中谷胱甘肽合成酶的鉴定。
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The determination of glycine in biological fluids.生物体液中甘氨酸的测定。
Clin Chim Acta. 1970 Jul;29(1):67-71. doi: 10.1016/0009-8981(70)90222-6.
5
The haemolytic effects of diaphenylsulfone (DDS) in normal subjects and in those with glucose-6-phosphate-dehydrogenase deficiency.二苯砜（DDS）对正常受试者及葡萄糖-6-磷酸脱氢酶缺乏者的溶血作用。
Bull World Health Organ. 1966;35(2):165-79.
6
Effect of insulin on muscle glutamate uptake. Whole blood versus plasma glutamate analysis.胰岛素对肌肉谷氨酸摄取的影响。全血与血浆谷氨酸分析。
J Clin Invest. 1972 Nov;51(11):2889-94. doi: 10.1172/JCI107112.
7
The effect of methylene blue and diaminodiphenysulfone on red cell reduced glutathione synthesis.亚甲蓝和二氨基二苯砜对红细胞还原型谷胱甘肽合成的影响。
J Lab Clin Med. 1972 Oct;80(4):481-7.
8
Pyroglutamic aciduria. Studies in an infant with chronic metabolic acidosis.焦谷氨酸尿症。对一名患有慢性代谢性酸中毒婴儿的研究。
Acta Paediatr Scand. 1974 Jan;63(1):1-8. doi: 10.1111/j.1651-2227.1974.tb04342.x.
9
Relationship of in vivo erythrocyte glutathione flux to the oxidized glutathione transport system.体内红细胞谷胱甘肽通量与氧化型谷胱甘肽转运系统的关系。
J Lab Clin Med. 1974 Mar;83(3):444-50.
10
Studies in the enzymology of glutathione metabolism in human erythrocytes.人类红细胞中谷胱甘肽代谢的酶学研究。
Biochem J. 1969 Feb;111(3):309-15. doi: 10.1042/bj1110309.