宿主体内利什曼原虫种群的调控。II. 小鼠对杜氏利什曼原虫感染急性易感性的遗传控制。
Regulation of Leishmania populations within the host. II. genetic control of acute susceptibility of mice to Leishmania donovani infection.
作者信息
Bradley D J
出版信息
Clin Exp Immunol. 1977 Oct;30(1):130-40.
Abstract
The acute growth rates of Leishmania donovani populations in twenty-five inbred mouse strains fall into two distinct groups: the susceptible (S) and the resistant (R). Hybrids within either category resemble their parents in susceptibility. Hybrids between categories are moderately resistant. Back-crossing of F1 hybrids to R and S parents, and interbreeding the F1 generation, give susceptibility ratios consistent with single gene control of acute susceptibility to visceral leishmaniasis. The distribution of this character among inbred mouse strains does not correspond to any well-studied gene nor does it appear to be linked to the H2 histocompatibility locus.
摘要
杜氏利什曼原虫在25种近交系小鼠品系中的急性生长率分为两个不同的组：易感组（S）和抗性组（R）。同一类别内的杂交种在易感性方面与其亲本相似。不同类别之间的杂交种具有中等抗性。F1杂交种与R和S亲本回交，以及F1代相互交配，得出的易感性比率与内脏利什曼病急性易感性的单基因控制一致。该性状在近交系小鼠品系中的分布与任何经过充分研究的基因均不对应，也似乎与H2组织相容性位点无关。
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