宿主体内利什曼原虫种群的调控。III. 小鼠内脏利什曼病易感性控制基因座的定位。
Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse.
作者信息
Bradley D J, Taylor B A, Blackwell J, Evans E P, Freeman J
出版信息
Clin Exp Immunol. 1979 Jul;37(1):7-14.
Abstract
Acute susceptibility of the mouse to Leishmania donovani is largely determined by a single locus designated Lsh. Linkage between the Lsh locus and the Chromosome 1 marker Id-1 was detected using several sets of recombinant inbred strains. Chromosome 1 linkage was confirmed in backcross generations using isoenzymes and a cytogenetic marker. The data indicate that the gene order is centromere-Lsh-Id-1-ln-Dip-1. The estimated recombination frequency between Lsh and Id-1 is 0.12 +/- 0.04. This mapping is away from the known histocompatibility loci.
摘要
小鼠对杜氏利什曼原虫的急性易感性在很大程度上由一个名为Lsh的单一位点决定。利用几组重组近交系检测了Lsh位点与1号染色体标记Id-1之间的连锁关系。使用同工酶和细胞遗传学标记在回交世代中证实了1号染色体的连锁关系。数据表明基因顺序为着丝粒-Lsh-Id-1-ln-Dip-1。Lsh和Id-1之间估计的重组频率为0.12±0.04。这种定位远离已知的组织相容性位点。
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