宿主体内利什曼原虫种群的调控。III. 小鼠内脏利什曼病易感性控制基因座的定位。
Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse.
作者信息
Bradley D J, Taylor B A, Blackwell J, Evans E P, Freeman J
出版信息
Clin Exp Immunol. 1979 Jul;37(1):7-14.
Abstract
Acute susceptibility of the mouse to Leishmania donovani is largely determined by a single locus designated Lsh. Linkage between the Lsh locus and the Chromosome 1 marker Id-1 was detected using several sets of recombinant inbred strains. Chromosome 1 linkage was confirmed in backcross generations using isoenzymes and a cytogenetic marker. The data indicate that the gene order is centromere-Lsh-Id-1-ln-Dip-1. The estimated recombination frequency between Lsh and Id-1 is 0.12 +/- 0.04. This mapping is away from the known histocompatibility loci.
摘要
小鼠对杜氏利什曼原虫的急性易感性在很大程度上由一个名为Lsh的单一位点决定。利用几组重组近交系检测了Lsh位点与1号染色体标记Id-1之间的连锁关系。使用同工酶和细胞遗传学标记在回交世代中证实了1号染色体的连锁关系。数据表明基因顺序为着丝粒-Lsh-Id-1-ln-Dip-1。Lsh和Id-1之间估计的重组频率为0.12±0.04。这种定位远离已知的组织相容性位点。
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本文引用的文献
1
Inbreeding and Linkage.
Genetics. 1931 Jul;16(4):357-74. doi: 10.1093/genetics/16.4.357.
2
MOUSE MACROPHAGES AS HOST CELLS FOR THE MOUSE HEPATITIS VIRUS AND THE GENETIC BASIS OF THEIR SUSCEPTIBILITY.
Proc Natl Acad Sci U S A. 1960 Aug;46(8):1065-75. doi: 10.1073/pnas.46.8.1065.
3
Protein and vitamin intake and visceral leishmaniasis in the mouse.
Exp Parasitol. 1960 Sep;10:1-20. doi: 10.1016/0014-4894(60)90078-3.
4
The inheritance of susceptibility to the Gross leukemia virus in mice.
Genetics. 1966 Mar;53(3):529-39. doi: 10.1093/genetics/53.3.529.
5
Letter: Genetic control of natural resistance to Leishmania donovani.
Nature. 1974 Jul 26;250(464):353-4. doi: 10.1038/250353a0.
6
The mouse liver aldehyde oxidase locus (Aox).
Biochem Genet. 1972 Apr;6(2):195-204. doi: 10.1007/BF00486403.
7
Genetics of resistance to infection with Salmonella typhimurium in mice.
J Infect Dis. 1976 Jan;133(1):72-8. doi: 10.1093/infdis/133.1.72.
8
The HLA system: introduction.
Br Med Bull. 1978 Sep;34(3):213-6. doi: 10.1093/oxfordjournals.bmb.a071500.
9
Regulation of Leishmania populations within the host. II. genetic control of acute susceptibility of mice to Leishmania donovani infection.
Clin Exp Immunol. 1977 Oct;30(1):130-40.
10
Regulation of Leishmania populations within the host. I. the variable course of Leishmania donovani infections in mice.
Clin Exp Immunol. 1977 Oct;30(1):119-29.
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