静脉输注短小棒状杆菌的并发症。
The complications of intravenous Corynebacterium parvum infusion.
作者信息
Gill P G, Morris P J, Kettlewell M
出版信息
Clin Exp Immunol. 1977 Nov;30(2):229-32.
Abstract
100 intravenous infusions of Corynebacterium parvum were given to thirty-six patients at a dose of 5 mg/m2. Fever and rigors occurred in all patients but these acute side effects were acceptable to all but two patients. Seventeen patients suffered a delayed fall in blood pressure, which was marked in eight of them but was generally well tolerated. One patient died 18 hr after infusion from extensive myocardial infarction. Herpes labialis complicated the first infusion in nine instances, which may reflect transient immunosuppression following immunotherapy.
摘要
给36名患者静脉输注小棒状杆菌100次，剂量为5mg/m²。所有患者均出现发热和寒战，但除两名患者外，这些急性副作用均为可接受。17名患者出现血压延迟下降，其中8名患者下降明显，但总体耐受性良好。一名患者在输注后18小时因广泛心肌梗死死亡。唇疱疹在9例首次输注时出现并发症，这可能反映了免疫治疗后短暂的免疫抑制。
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[Corynebacterium parvum in advanced cancers. 1st evaluation of the therapeutic activity of this immunostimulin].[微小棒状杆菌用于晚期癌症。对这种免疫刺激素治疗活性的首次评估]
Nouv Presse Med. 1972 Jan 1;1(1):19-23.
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