高钾离子（K⁺）和多巴胺对下丘脑突触体中免疫反应性生长抑素释放的刺激作用。

Stimulation of immunoreactive somatostatin release from hypothalamic synaptosomes by high (K+) and dopamine.

作者信息

Wakabayashi I, Miyazawa Y, Kanda M, Miki N, Demura R, Demura H, Shizume K

出版信息

Endocrinol Jpn. 1977 Dec;24(6):601-4. doi: 10.1507/endocrj1954.24.601.

DOI:10.1507/endocrj1954.24.601

Abstract

Effects of high (K+) and dopamine on the release of immunoreactive somatostatin from isolated hypothalamic synaptosomes were studied in rats. High (K+) (60 mM) and dopamine (10(-6) M) in the incubation media stimulated the release of immunoreactive somatostatin and the former effect was completely abolished by the removal of Ca++ from the media. These suggest that hypothalamic somatostatinergic synaptosomes preserved at least one of the important basic properties of secretory cells. Although it is of interest to note that dopamine stimulated the release of somatostatin. Its physiological significance awaits further studies.

摘要

在大鼠中研究了高钾（K⁺）和多巴胺对离体下丘脑突触体中免疫反应性生长抑素释放的影响。孵育培养基中的高钾（60 mM）和多巴胺（10⁻⁶ M）刺激了免疫反应性生长抑素的释放，并且通过从培养基中去除钙离子，前一种效应被完全消除。这些表明下丘脑生长抑素能突触体保留了分泌细胞至少一种重要的基本特性。尽管值得注意的是多巴胺刺激了生长抑素的释放，但其生理意义有待进一步研究。