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The effect of nacom (L-dopa and L-carbidopa) on growth hormone secretion in 75 patients with short stature.

作者信息

Schönberger W, Grimm W, Ziegler R

出版信息

Eur J Pediatr. 1977 Dec 30;127(1):15-9. doi: 10.1007/BF00465561.

DOI:10.1007/BF00465561
PMID:606555
Abstract

The stimulatory effect of Nacom (250 mg L-Dopa and 25 mg L-Carbidopa) on the HGH secretion was evaluated in 75 short stature patients. The number of blood samples was restricted to only three (0, 45 and 90 min). 63 patients reached adequate HGH concentrations after the ingestion of 1 tablet Nacom (84%). Somatotropin levels increased from 2.08 (Sx 0.28) to a maximal HGH value of 14.22 (Sx 0.87) ng/ml. When the stimulatory effect of Nacom was compared with the standard method of arginine infusion in children with normal stature the arginine test was not superior to the Nacom-test. The Nacom-test appears to be a simple and reliable screening method for HGH deficiency, particularly in outpatients.

摘要

相似文献

1
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2
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本文引用的文献

1
Adrenergic receptor control mechanism for growth hormone secretion.生长激素分泌的肾上腺素能受体控制机制。
J Clin Invest. 1968 Jun;47(6):1407-14. doi: 10.1172/JCI105832.
2
Stimulation of human-growth-hormone secretion by L-dopa.左旋多巴对人体生长激素分泌的刺激作用。
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3
Exercise as a screening test for growth hormone release.运动作为生长激素释放的筛查试验。
脑儿茶酚胺和乙酰胆碱与生长激素缺乏状态的关系。病理生理学、诊断及治疗意义。
Drugs. 1991 Feb;41(2):161-77. doi: 10.2165/00003495-199141020-00002.
Acta Endocrinol (Copenh). 1972 Feb;69(2):219-29. doi: 10.1530/acta.0.0690219.
4
[Growth hormone examinations in 225 children with dwarfism].[225例侏儒症患儿的生长激素检查]
Schweiz Med Wochenschr. 1972 Jun 3;102(22):760-5.
5
Apparent inadequency of L-dopa stimulation as a clinical test of growth hormone release.左旋多巴刺激作为生长激素释放的临床测试存在明显不足。
J Clin Endocrinol Metab. 1972 Jun;34(6):1105-7. doi: 10.1210/jcem-34-6-1105.
6
Human growth hormone secretion after exercise and oral glucose administration in patients with short stature.身材矮小患者运动及口服葡萄糖后生长激素的分泌情况
J Clin Endocrinol Metab. 1972 Jun;34(6):1055-8. doi: 10.1210/jcem-34-6-1055.
7
L-DOPA and pituitary hormone secretion.左旋多巴与垂体激素分泌
J Clin Endocrinol Metab. 1972 May;34(5):764-6. doi: 10.1210/jcem-34-5-764.
8
Effects of autonomic blocking agents on growth hormone, insulin, free fatty acids and glucose in baboons.自主神经阻断剂对狒狒生长激素、胰岛素、游离脂肪酸和葡萄糖的影响。
Endocrinology. 1970 Jan;86(1):77-82. doi: 10.1210/endo-86-1-77.
9
Exercise as a screening test for growth hormone deficiency in children.运动作为儿童生长激素缺乏症的筛查测试。
Arch Dis Child. 1973 Jul;48(7):508-12. doi: 10.1136/adc.48.7.508.
10
The use of L-DOPA in the diagnosis of hyposomatotropism in children.左旋多巴在儿童生长激素缺乏症诊断中的应用。
J Clin Endocrinol Metab. 1973 Jan;36(1):42-6. doi: 10.1210/jcem-36-1-42.