低剂量卡比多巴/左旋多巴对乳腺癌患者及乳腺良性肿瘤患者催乳素和生长激素浓度的影响。
The effect of low dose carbidopa/levodopa on prolactin and growth hormone concentrations in patients with breast cancer and in benign breast tumours.
作者信息
Jones M K, Ramsay I D, Jenner P G
出版信息
Br J Clin Pharmacol. 1978 May;5(5):425-30. doi: 10.1111/j.1365-2125.1978.tb01649.x.
Abstract
1 Low doses of carbidopa/levodopa (12.5 mg 1-alpha-methyl-dopahydrazine, 125 mg levodopa) were administered orally to 29 patients with tumours of the breast (16 with breast cancer, 13 with benign breast disease). 2 Plasma dopa response curves were similar in all the patients studied. 3 Prolactin and growth hormone showed similar responses to carbidopa/levodopa irrespective of age or diagnosis. 4 Prolactin showed an unusual reponse in four patients which has not previously been recorded.
摘要
- 对29例乳腺肿瘤患者（16例乳腺癌患者，13例乳腺良性疾病患者）口服低剂量的卡比多巴/左旋多巴（12.5毫克1-α-甲基多巴肼，125毫克左旋多巴）。2. 所有研究患者的血浆多巴反应曲线相似。3. 无论年龄或诊断情况如何，催乳素和生长激素对卡比多巴/左旋多巴均表现出相似反应。4. 4例患者的催乳素表现出一种以前未记录过的异常反应。
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The effect of low dose carbidopa/levodopa on prolactin and growth hormone concentrations in patients with breast cancer and in benign breast tumours.低剂量卡比多巴/左旋多巴对乳腺癌患者及乳腺良性肿瘤患者催乳素和生长激素浓度的影响。
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Potentiation of levodopa stimulation of human growth hormone by systemic decarboxylase inhibition.通过全身性脱羧酶抑制增强左旋多巴对人生长激素的刺激作用。
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