低剂量卡比多巴/左旋多巴对乳腺癌患者及乳腺良性肿瘤患者催乳素和生长激素浓度的影响。
The effect of low dose carbidopa/levodopa on prolactin and growth hormone concentrations in patients with breast cancer and in benign breast tumours.
作者信息
Jones M K, Ramsay I D, Jenner P G
出版信息
Br J Clin Pharmacol. 1978 May;5(5):425-30. doi: 10.1111/j.1365-2125.1978.tb01649.x.
Abstract
1 Low doses of carbidopa/levodopa (12.5 mg 1-alpha-methyl-dopahydrazine, 125 mg levodopa) were administered orally to 29 patients with tumours of the breast (16 with breast cancer, 13 with benign breast disease). 2 Plasma dopa response curves were similar in all the patients studied. 3 Prolactin and growth hormone showed similar responses to carbidopa/levodopa irrespective of age or diagnosis. 4 Prolactin showed an unusual reponse in four patients which has not previously been recorded.
摘要
- 对29例乳腺肿瘤患者（16例乳腺癌患者，13例乳腺良性疾病患者）口服低剂量的卡比多巴/左旋多巴（12.5毫克1-α-甲基多巴肼，125毫克左旋多巴）。2. 所有研究患者的血浆多巴反应曲线相似。3. 无论年龄或诊断情况如何，催乳素和生长激素对卡比多巴/左旋多巴均表现出相似反应。4. 4例患者的催乳素表现出一种以前未记录过的异常反应。
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本文引用的文献
1
Stimulation of human-growth-hormone secretion by L-dopa.
N Engl J Med. 1970 Dec 24;283(26):1425-9. doi: 10.1056/NEJM197012242832602.
2
Parkinson's disease: activity of L-dopa decarboxylase in discrete brain regions.
Science. 1970 Dec 11;170(3963):1212-3. doi: 10.1126/science.170.3963.1212.
3
Dihydroxyphenylalanine (DOPA) in plasma during dopa treatment of patients with Parkinson's disease.
Mayo Clin Proc. 1970 Jun;45(6):438-43.
4
Dopamine (3-hydroxytyramine) and brain function.
Pharmacol Rev. 1966 Jun;18(2):925-64.
5
Local excision and irradiation: an alternative method for the treatment of early mammary cancer.
Ann Surg. 1971 Sep;174(3):392-401. doi: 10.1097/00000658-197109000-00008.
6
A method for the determination of dopa and 3-O-methyldopa in the plasma of Parkinsonian patients.
Clin Chim Acta. 1972 Mar;37:335-41. doi: 10.1016/0009-8981(72)90453-6.
7
Hypophysial portal vessel infusion: in vivo demonstration of LRF, FRF, and PIF in pituitary stalk plasma.
Endocrinology. 1971 Oct;89(4):1042-6. doi: 10.1210/endo-89-4-1042.
8
Effects of 2-Br-alpha-Ergocryptine, L-dopa and cyclic imides on serum prolactin in postmenopausal women.
Eur J Cancer (1965). 1973 Sep;9(9):657-64. doi: 10.1016/0014-2964(73)90008-x.
9
Plasma prolactin in breast cancer.
Eur J Cancer (1965). 1973 Feb;9(2):99-102. doi: 10.1016/0014-2964(73)90078-9.
10
Potentiation of levodopa stimulation of human growth hormone by systemic decarboxylase inhibition.
Clin Pharmacol Ther. 1973 May-Jun;14(3):390-5. doi: 10.1002/cpt1973143390.
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