肾上腺素对人体血小板的作用。
Effects of adrenaline on human blood platelets.
作者信息
Mills D C, Roberts G C
出版信息
J Physiol. 1967 Nov;193(2):443-53. doi: 10.1113/jphysiol.1967.sp008369.
Abstract
- Adrenaline at concentrations too low to cause aggregation of human platelets potentiates the aggregation by adenosine diphosphate. Noradrenaline has the same effect but is less active than adrenaline; isopropylnoradrenaline is inactive or inhibitory.2. The potentiation of adenosine diphosphate by catecholamines is blocked by the adrenergic alpha-receptor antagonists phentolamine and dihydroergotamine but not by 2-halogenoethylamines or by adrenergic beta-receptor antagonists.3. Both the first and second phases of adenosine diphosphate aggregation are potentiated by catecholamines but the second phase more than the first.4. The release from the platelets of adenine nucleotides which is associated with the second phase of aggregation is also increased by adrenaline.
摘要
- 肾上腺素浓度过低时不会引起人体血小板聚集，但可增强二磷酸腺苷（ADP）所致的血小板聚集作用。去甲肾上腺素具有同样的作用，但活性比肾上腺素低；异丙基去甲肾上腺素则无活性或具有抑制作用。2. 儿茶酚胺对二磷酸腺苷的增强作用可被肾上腺素能α受体拮抗剂酚妥拉明和双氢麦角胺阻断，但不能被2-卤代乙胺或肾上腺素能β受体拮抗剂阻断。3. 儿茶酚胺可增强二磷酸腺苷聚集的第一相和第二相，但对第二相的增强作用比对第一相的增强作用更明显。4. 与聚集第二相相关的血小板腺嘌呤核苷酸释放也可被肾上腺素增加。
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