重性抑郁障碍患者的内皮素和血小板 5-羟色胺摄取。
Ect and platelet 5ht uptake in major depression.
机构信息
P.K. DALAL, MD., Associate Professor, Department of Psychiatry, K.G'S Medical College, Lucknow-226003.
出版信息
Indian J Psychiatry. 1997 Oct;39(4):272-7.
Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The mechanism of antidepressant action of ECT is not clear. The present work was undertaken with the aim to study the active platelet 5-HT uptake and the effect of ECT on it in patients of major depression. 15 patients of major depression (DSM-lll-R) and equal number of age and sex-matched controls were included in the study. Active platelet 5-HT uptake was determined before ECT, after a course of ECT and 7 days after last ECT. Platelet 5-HT uptake was. significantly lower in der essives than normal controls. After ECT treatment there was significant increase in 5-HT uptake which came down to pretreatment level after 1 week of last ECT. The effect of ECT on serotonergic system is discussed.
几项研究报道了重度抑郁症患者血小板 5-HT 摄取减少。ECT 的抗抑郁作用机制尚不清楚。本研究旨在研究重度抑郁症患者的活性血小板 5-HT 摄取以及 ECT 对其的影响。15 名重度抑郁症（DSM-lll-R）患者和年龄、性别匹配的对照组患者纳入本研究。在 ECT 前、ECT 疗程结束后和最后一次 ECT 后 7 天测定活性血小板 5-HT 摄取。抑郁症组血小板 5-HT 摄取显著低于对照组。ECT 治疗后，5-HT 摄取显著增加，最后一次 ECT 后 1 周降至治疗前水平。讨论了 ECT 对 5-羟色胺能系统的影响。
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