Wise T G, Dolin R, Mazur M H, Ennis F A
J Infect Dis. 1977 Dec;136 Suppl:S496-9. doi: 10.1093/infdis/136.supplement_3.s496.
The serologic responses after two sequential nonreactive doses of either chemically disrupted or whole-virus influenza A/New Jersey/76 virus vaccine were evaluated in 112 normal young adults. In general, levels of hemagglutination-inhibiting (HAI) antibody were low after the first dose of vaccine and increased significantly (P less than 0.05) in response to a second dose. Whereas one dose of the preparation from Merck Sharp and Dohme (West Point, Pa.) effectively vaccinated this population, two doses of the vaccines prepared by Parke, Davis and Company (Detroit, Mich.) and Merrell-National Laboratories (Cincinnati, Ohio) were required to produce a similar serologic response. The preparation from Wyeth Laboratories (Philadelphia, Pa.) produced low levels of HAI antibodies even after two doses. These different serologic responses correlated with the viral hemagglutinin content of each vaccine.
在112名正常年轻成年人中评估了两剂连续的化学裂解或全病毒甲型流感/新泽西/76病毒疫苗后的血清学反应。总体而言，首剂疫苗后血凝抑制（HAI）抗体水平较低，而在接种第二剂后显著升高（P<0.05）。虽然一剂默克夏普&多贺美公司（宾夕法尼亚州西点）的制剂有效地为该人群提供了疫苗接种，但帕克-戴维斯公司（密歇根州底特律）和梅里尔-国家实验室（俄亥俄州辛辛那提）制备的疫苗需要两剂才能产生类似的血清学反应。惠氏实验室（宾夕法尼亚州费城）的制剂即使在两剂后也产生低水平的HAI抗体。这些不同的血清学反应与每种疫苗的病毒血凝素含量相关。
