用各种改性卟啉和金属卟啉制备的抹香鲸肌红蛋白的免疫化学。
Immunochemistry of sperm-whale myoglobins prepared with various modified porphyrins and metalloporphyrins.
作者信息
Atassi M Z
出版信息
Biochem J. 1967 Apr;103(1):29-35. doi: 10.1042/bj1030029.
Abstract
- The preparation and characterization of manganese, iron, cobalt, nickel, copper and zinc metalloporphyrins is described. Ferrihaem was also esterified with pyrid-4-ylpropanol and the derivative characterized as the diester. 2. Complexes of these various porphyrins, as well as protoporphyrin IX, with apomyoglobin were formed and the resulting artificial myoglobins characterized. 3. Very little complex-formation was obtained with nickel, cobalt and manganese metalloporphyrins and apomyoglobin. 4. Myoglobin prepared with copper metalloporphyrin was immunochemically identical with native ferrimyoglobin. All the other artificial myoglobins were less reactive to varying degrees. 5. The changes in antigenic reactivities were attributed to conformational reorganization caused by the different co-ordination tendencies of the various metals or by the modification of the side chains of the haem.
摘要
- 描述了锰、铁、钴、镍、铜和锌金属卟啉的制备及表征。高铁血红素也用4-吡啶基丙醇进行酯化，并将该衍生物表征为二酯。2. 这些各种卟啉以及原卟啉IX与脱辅基肌红蛋白形成复合物，并对所得的人工肌红蛋白进行表征。3. 镍、钴和锰金属卟啉与脱辅基肌红蛋白形成的复合物很少。4. 用铜金属卟啉制备的肌红蛋白在免疫化学上与天然亚铁肌红蛋白相同。所有其他人工肌红蛋白在不同程度上反应性较低。5. 抗原反应性的变化归因于各种金属不同的配位倾向或血红素侧链的修饰引起的构象重组。
相似文献
1
Immunochemistry of sperm-whale myoglobins prepared with various modified porphyrins and metalloporphyrins.用各种改性卟啉和金属卟啉制备的抹香鲸肌红蛋白的免疫化学。
Biochem J. 1967 Apr;103(1):29-35. doi: 10.1042/bj1030029.
2
The Porphyromonas gingivalis HmuY haemophore binds gallium(iii), zinc(ii), cobalt(iii), manganese(iii), nickel(ii), and copper(ii) protoporphyrin IX but in a manner different to iron(iii) protoporphyrin IX.牙龈卟啉单胞菌 HmuY 血卟啉结合镓(III)、锌(II)、钴(III)、锰(III)、镍(II)和铜(II)原卟啉 IX，但与铁(III)原卟啉 IX 的结合方式不同。
Metallomics. 2013 Apr;5(4):343-51. doi: 10.1039/c3mt20215a.
3
Conformational studies on modified proteins and peptides. Artificial myoglobins prepared with modified and metalloporphyrins.修饰蛋白质和肽的构象研究。用修饰的金属卟啉制备的人工肌红蛋白。
Biochemistry. 1970 May 26;9(11):2268-75. doi: 10.1021/bi00813a007.
4
The meso-reactivity of porphyrins and related compounds. V. The meso-oxidation of metalloporphyrins.卟啉及相关化合物的中位反应活性。V. 金属卟啉的中位氧化
J Chem Soc Perkin 1. 1972;20:2540-8. doi: 10.1039/p19720002540.
5
ENZYMIC FORMATION OF HAEMS AND OTHER METALLOPORPHYRINS.血红素及其他金属卟啉的酶促形成
Biochim Biophys Acta. 1964 Oct 9;93:171-3. doi: 10.1016/0304-4165(64)90273-9.
6
Absorption spectra of sperm-whale ferrimyoglobin.抹香鲸高铁肌红蛋白的吸收光谱。
Biochem J. 1966 Jan;98(1):189-92. doi: 10.1042/bj0980189.
7
COMBINATION OF PROTOPORPHYRIN IX WITH SPERM WHALE APOMYOGLOBIN.原卟啉IX与抹香鲸脱辅基肌红蛋白的结合
J Biol Chem. 1965 May;240:2266-8.
8
KINETICS OF THE REVERSIBLE REACTION OF SPERM WHALE MYOGLOBIN WITH ZINC.抹香鲸肌红蛋白与锌的可逆反应动力学
Biochemistry. 1964 May;3:714-22. doi: 10.1021/bi00893a020.
9
Preparation and O2 binding study of myoglobin having a cobalt porphycene.含钴卟吩肌红蛋白的制备及氧气结合研究
Inorg Chem. 2005 Dec 12;44(25):9391-6. doi: 10.1021/ic0513639.
10
Immunochemistry of sperm whale myoglobin. VI. Preparation and conformational analysis of eight mammalian myoglobins.抹香鲸肌红蛋白的免疫化学。VI. 八种哺乳动物肌红蛋白的制备及构象分析。
Biochim Biophys Acta. 1970 Dec 22;221(3):612-22. doi: 10.1016/0005-2795(70)90233-3.
引用本文的文献
1
Crystal structures of manganese- and cobalt-substituted myoglobin in complex with NO and nitrite reveal unusual ligand conformations.与一氧化氮和亚硝酸盐结合的锰和钴取代肌红蛋白的晶体结构揭示了异常的配体构象。
J Inorg Biochem. 2008 Feb;102(2):216-33. doi: 10.1016/j.jinorgbio.2007.08.002. Epub 2007 Aug 25.
2
Immunologically reactive tryptic fragments of human prostatic acid phosphatase.人前列腺酸性磷酸酶的免疫反应性胰蛋白酶片段
Biochem J. 1984 Nov 1;223(3):871-7. doi: 10.1042/bj2230871.
3
The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species.对肌红蛋白的抗体反应与免疫物种无关。分析了在不同物种中产生的十五种肌红蛋白与抹香鲸肌红蛋白抗血清交叉反应的抗原位点和环境残基中的替换情况。
Biochem J. 1980 Dec 1;191(3):681-97. doi: 10.1042/bj1910681.
4
Nearest-neighbour analysis of myoglobin antigenic sites. Nearest-neighbour residues whose replacement can alter the environment of binding-site residue(s) and thus change their characteristics and binding capability.肌红蛋白抗原位点的最近邻分析。其取代可改变结合位点残基环境从而改变其特性和结合能力的最近邻残基。
Biochem J. 1980 Dec 1;191(3):673-80. doi: 10.1042/bj1910673.
5
Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites.蛋白质抗原结构的精确测定揭示了蛋白质的分子免疫识别，并为其他蛋白质结合位点的合成模拟提供了原型。
Mol Cell Biochem. 1980 Aug 29;32(1):21-43. doi: 10.1007/BF00421293.
6
A study of the reaction of protoporphyrin IX with human globin.原卟啉IX与人珠蛋白反应的研究。
Biochem J. 1974 Feb;137(2):319-29. doi: 10.1042/bj1370319.
7
T-cell recognition and antigen presentation of myoglobin. Protein recognition by site-specific T-cell clones is influenced by amino acid substitutions outside the site.肌红蛋白的T细胞识别与抗原呈递。位点特异性T细胞克隆对蛋白质的识别受该位点以外氨基酸取代的影响。
Biochem J. 1989 Mar 15;258(3):645-51. doi: 10.1042/bj2580645.
8
Delineation of the third antigenic site of lysozyme by application of a novel 'surface-simulation' synthetic approach directly linking the conformationally adjacent residues forming the site.通过应用一种新颖的“表面模拟”合成方法直接连接形成该位点的构象相邻残基，来描绘溶菌酶的第三个抗原位点。
Biochem J. 1976 Oct 1;159(1):89-93. doi: 10.1042/bj1590089.
9
Boundary refinement of the lysozyme antigenic site around the disulphide bond 6-127 (site 1) by 'surface-simulation' synthesis.通过“表面模拟”合成对围绕二硫键6-127（位点1）的溶菌酶抗原位点进行边界优化。
Biochem J. 1978 May 1;171(2):419-27. doi: 10.1042/bj1710419.
10
Enzymic and immunochemical properties of lysozyme. Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by 'surface-simulation' synthesis.溶菌酶的酶学和免疫化学特性。通过“表面模拟”合成精确定义二硫键30-115周围的抗原位点（位点3）。
Biochem J. 1977 Dec 1;167(3):571-81. doi: 10.1042/bj1670571.
本文引用的文献
1
The immunological activity of some of the chymotryptic peptides of sperm-whale myoglobin.抹香鲸肌红蛋白某些胰凝乳蛋白酶肽段的免疫活性
Biochem J. 1965 Mar;94(3):545-56. doi: 10.1042/bj0940545.
2
A steam distillation apparatus suitable for micro-Kjeldahl analysis.一种适用于微量凯氏定氮分析的水蒸气蒸馏装置。
Biochem J. 1942 Dec;36(10-12):790-1. doi: 10.1042/bj0360790.
3
The Preparation and some Properties of the Globin of Oxyhaemoglobin.氧合血红蛋白珠蛋白的制备及其某些性质
Biochem J. 1926;20(6):1326-39. doi: 10.1042/bj0201326.
4
Light scattering and sedimentation of native human adult and fetal globin.天然成人及胎儿血红蛋白的光散射与沉降
J Biol Chem. 1959 Nov;234:2906-10.
5
PROPERTIES OF COMPONENTS OF MYOGLOBIN OF THE SPERM WHALE.抹香鲸肌红蛋白成分的特性
Nature. 1964 May 2;202:496-8. doi: 10.1038/202496a0.
6
IMMUNOCHEMICAL STUDIES OF HEMOGLOBIN AND MYOGLOBIN AND THEIR GLOBIN MOIETIES.血红蛋白和肌红蛋白及其珠蛋白部分的免疫化学研究。
Biochemistry. 1963 Sep-Oct;2:971-9. doi: 10.1021/bi00905a013.
7
Haem-globin equilibrium studies by fluorimetry.通过荧光法进行血红蛋白平衡研究。
Biochim Biophys Acta. 1959 Sep;35:289-91. doi: 10.1016/0006-3002(59)90376-2.
8
The amino-acid sequence x-ray methods, and its correlation with chemical data.氨基酸序列的X射线方法及其与化学数据的关联。
Nature. 1961 May 20;190:666-70. doi: 10.1038/190666a0.
9
Starch gel electrophoresis in a discontinous system of buffers.在不连续缓冲系统中的淀粉凝胶电泳。
Nature. 1957 Dec 28;180(4600):1477-9. doi: 10.1038/1801477a0.
10
The chemistry of anti-pernicious anaemia factors. XI. The preparation and properties of some cobalt porphyrins.抗恶性贫血因子的化学。十一、某些钴卟啉的制备与性质
J Pharm Pharmacol. 1953 Mar;5(3):179-95. doi: 10.1111/j.2042-7158.1953.tb13974.x.
Zotero 插件