Nakao M, Nagaishi T, Inoue M, Kimachi H, Koga S
Jpn J Surg. 1977 Dec;7(4):269-78. doi: 10.1007/BF02469361.
To elucidate the mechanism of portal hypertension seen as a symptom of so-called Banti's syndrome (idiopathic portal hypertension), observation was made of rising of the portal pressure experimentally induced in sensitized rabbits. Intraintestinal injection of the same antigen as used for the sensitization resulted in elevation of the portal pressure. This phenomenon appears to be attributable to antigen-antibody reaction caused by the injected antigen absorbed from the intestine and entered thereby into the portal system while maintaining its antigenicity. From the phenomenon also, the site of the antigen-antibody reaction is estimated to be limited at least to the hepatic level. The portal pressure-rising phenomenon observed following intraintestinal introduction of antigen may suggest the possibility of entrance of the orally introduced antigen to the portal system, emphasizes importance of alimentary factors in the genesis of this syndrome.
为阐明所谓班替氏综合征（特发性门静脉高压症）所表现出的门静脉高压的机制，对致敏兔实验性诱导的门静脉压力升高进行了观察。向肠道内注射与致敏所用相同的抗原会导致门静脉压力升高。这种现象似乎归因于从肠道吸收并进入门静脉系统的注射抗原在保持其抗原性的同时引发的抗原 - 抗体反应。根据这一现象，抗原 - 抗体反应的部位估计至少局限于肝脏水平。肠道内引入抗原后观察到的门静脉压力升高现象可能提示经口引入的抗原进入门静脉系统的可能性，强调了饮食因素在该综合征发生中的重要性。
