大鼠和豚鼠肝脏中乙醇脱氢酶活性的发育变化
Developmental changes in alcohol-dehydrogenase activity in rat and guinea-pig liver.
作者信息
Räihä N C, Koskinen M, Pikkarainen P
出版信息
Biochem J. 1967 Jun;103(3):623-6. doi: 10.1042/bj1030623.
Abstract
- Alcohol-dehydrogenase activity is first detectable in the rat foetus on about the eighteenth day of gestation, after which time it increases to about 25% of the adult activity at birth. Adult activity is reached at about 18 days after birth. The ethanol-oxidizing capacity of liver slices from rats correlates well with the increase of the enzyme activity in vitro. 2. In the guinea pig there is a steady linear increase from about 17 days before term to 5 days after birth. Adult activity is reached between the sixth and eighth postnatal day. 3. Some kinetic properties of liver alcohol dehydrogenase are very similar in newborn and adult rats. 4. Administration of ethanol to pregnant rats during the latter half of gestation had no effect on alcohol-dehydrogenase activity in the liver of the newborn offspring. Intraperitoneal injections of ethanol to newborn and young rats had no effect on the alcohol-dehydrogenase activity of the livers. 5. Intraperitoneal injections of hydrocortisone and triamcinolone to newborn and adult non-adrenalectomized rats had no significant effect on the increase of the alcohol-dehydrogenase activity as studied up to 4 days after the injection.
摘要
- 酒精脱氢酶活性在妊娠约第18天时首次在大鼠胎儿中被检测到，此后其活性增加，至出生时达到成年活性的约25%。出生后约18天达到成年活性。大鼠肝切片的乙醇氧化能力与体外酶活性的增加密切相关。2. 在豚鼠中，从足月前约17天到出生后5天，其活性呈稳定的线性增加。出生后第6至8天达到成年活性。3. 新生大鼠和成年大鼠肝脏酒精脱氢酶的一些动力学特性非常相似。4. 在妊娠后半期给怀孕大鼠注射乙醇，对新生后代肝脏中的酒精脱氢酶活性没有影响。给新生大鼠和幼鼠腹腔注射乙醇，对其肝脏的酒精脱氢酶活性没有影响。5. 给新生大鼠和成年未切除肾上腺的大鼠腹腔注射氢化可的松和曲安西龙，在注射后长达4天的研究中，对酒精脱氢酶活性的增加没有显著影响。
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本文引用的文献
1
Nature and Development of Lactic Dehydrogenases: The two major types of this enzyme form molecular hybrids which change in makeup during development.乳酸脱氢酶的性质与发育：该酶的两种主要类型形成分子杂交体，其组成在发育过程中会发生变化。
Science. 1962 Jun 15;136(3520):962-9. doi: 10.1126/science.136.3520.962.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
[Specific photometric determination of ethyl alcohol based on an enzymatic reaction].基于酶促反应的乙醇特异性光度测定法
Klin Wochenschr. 1951 Sep 15;29(35-36):615-6. doi: 10.1007/BF01485653.
4
Some metabolic effects of ethyl alcohol.乙醇的一些代谢效应。
Am J Med. 1962 Sep;33:319-27. doi: 10.1016/0002-9343(62)90229-2.
5
Mechanisms controlling changes in tryptophan peroxidase activity in developing mammalian liver.发育中哺乳动物肝脏中色氨酸过氧化物酶活性变化的调控机制。
J Biol Chem. 1959 Nov;234:2921-4.
6
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Biochem J. 1965 Jan;94(1):259-65. doi: 10.1042/bj0940259.
7
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Lab Invest. 1965 Mar;14:264-71.
8
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9
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10
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