甲状腺切除术对泌乳期大鼠乳腺合成脂肪酸模式的影响。
The effect of thyroidectomy on the pattern of fatty acids synthesized by mammary gland from lactating rats.
作者信息
Greenbaum A L, Walters E, McLean P
出版信息
Biochem J. 1967 Jun;103(3):720-3. doi: 10.1042/bj1030720.
Abstract
Thyroidectomy decreased the content of short-chain fatty acids and increased the content of long-chain fatty acids in the mammary glands of lactating rats. This effect was replicated in the glands of untreated rats limited to the same food intake as the thyroidectomized animals. Thyroidectomy decreased the incorporation of [6-(14)C]glucose into short-chain fatty acids and increased the incorporation into longer-chain acids. Restriction of the food intake of untreated animals did not cause a similar shift of the incorporation pattern. The possibility that the thyroxine effect on lipogenesis is secondary to its effect on carbohydrate metabolism is discussed.
摘要
甲状腺切除术降低了泌乳大鼠乳腺中短链脂肪酸的含量，增加了长链脂肪酸的含量。这种效应在未处理大鼠的乳腺中也得到了重现，这些大鼠的食物摄入量与甲状腺切除的动物相同。甲状腺切除术减少了[6-(14)C]葡萄糖掺入短链脂肪酸的量，增加了其掺入长链脂肪酸的量。限制未处理动物的食物摄入量并未导致类似的掺入模式变化。文中讨论了甲状腺素对脂肪生成的影响可能继发于其对碳水化合物代谢的影响这一可能性。
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