细交链孢菌酮酸类似物的合成
Synthesis of tenuazonic acid analogues.
作者信息
Soliman F S
出版信息
Pharmazie. 1977 Oct;32(10):572-5.
PMID:607213
Abstract
The synthesis of two 1.5-diaryltetramic acids, aryl analogues of tenuazonic acid, is described. The reactivity of position 4 of these tetramic acids towards primary and secondary amines, and o-methylation led to the synthesis of 4-substituted-delta3-pyrroline-2-one. Further, reactivity of position 3 has been indicated by the formation of 3-arylidenepyrrolidine-2.4-diones and by diazo-coupling. The structures assigned to the new compounds are substantiated by IR and NMR data.
摘要
本文描述了两种1,5-二芳基四酰胺酸（细交链孢菌酮酸的芳基类似物）的合成。这些四酰胺酸4位对伯胺和仲胺的反应活性以及邻甲基化反应导致了4-取代-δ3-吡咯啉-2-酮的合成。此外，3-亚芳基吡咯烷-2,4-二酮的形成以及重氮偶合反应表明了3位的反应活性。通过红外光谱和核磁共振数据证实了所赋予新化合物的结构。
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