一种测定尿中δ-氨基乙酰丙酸的简化方法。
A simplified procedure for the determination of urinary delta-aminolaevulinic acid.
作者信息
Williams M K, Few J D
出版信息
Br J Ind Med. 1967 Oct;24(4):294-6. doi: 10.1136/oem.24.4.294.
Urinary δ-aminolaevulinic acid (ALA) is commonly estimated by the method of Mauzerall and Granick (1956). In that method porphobilinogen (PBG) and ALA are successively separated from the urine by ion exchange resins. A simplified procedure, omitting the initial separation of PBG, was investigated. Urine samples from 39 lead workers and controls were estimated for ALA by both the original procedure and by this simplified procedure. A correlation coefficient of 0·99 was obtained. It was concluded that the simplified procedure may be used for screening lead workers so long as the possibility of false high readings is borne in mind. Some sources of variation in standardizing the original procedure are also discussed.
尿δ-氨基乙酰丙酸（ALA）通常采用毛泽拉尔和格拉尼克（1956年）的方法进行测定。该方法通过离子交换树脂先后从尿液中分离出卟胆原（PBG）和ALA。研究了一种简化程序，省略了PBG的初始分离步骤。采用原始程序和这种简化程序对39名铅作业工人及对照者的尿液样本进行了ALA测定。得到的相关系数为0.99。得出的结论是，只要记住可能出现假高读数的情况，简化程序可用于筛查铅作业工人。还讨论了原始程序标准化过程中的一些变异来源。
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