Clark D G, Litchfield M H
Br J Ind Med. 1967 Oct;24(4):320-5. doi: 10.1136/oem.24.4.320.
Breakdown of ethylene glycol dinitrate (EGDN) in blood results in the liberation of inorganic nitrite and ethylene glycol mononitrate (EGMN). The nitrite is oxidized to inorganic nitrate but the EGMN is more resistant to further degradation. Similar metabolites are produced during the metabolism of EDGN . The nitrate is excreted in the urine and accounts for 60% of the injection. The EGMN released is almost completely metabolized, since only 1·5% of the injection can be detected as EGMN in the urine. Breakdown of EGMN is confirmed when the compound is injected; less than 0·5% is recovered as EGMN in the urine. Nitrite is released and oxidized to nitrate which is then excreted in the urine and accounts for 57% of the injection. An injection of EGDN or EGMN causes a fall in blood pressure lasting several hours, EGDN being more effective. Since the fall in blood pressure and the concentrations of EGDN and its metabolites in the blood have been determined simultaneously, a correlation between blood pressure and blood concentrations has been attempted. It is suggested that the fall in blood pressure after an injection of EGDN could be the resultant of the actions of EGDN, EGMN, and nitrite. The initial fall in blood pressure may be due to the intact molecule of EGDN followed in turn by the effects of nitrite and EGMN released during the breakdown of the EGDN molecule.
血液中乙二醇二硝酸酯（EGDN）分解会释放出无机亚硝酸盐和乙二醇单硝酸酯（EGMN）。亚硝酸盐会被氧化为无机硝酸盐，但EGMN更难进一步降解。在EDGN代谢过程中会产生类似的代谢产物。硝酸盐通过尿液排出，占注射量的60%。释放出的EGMN几乎完全被代谢，因为在尿液中只能检测到1.5%的注射量为EGMN。当注射该化合物时，EGMN的分解得到证实；尿液中回收的EGMN不到0.5%。亚硝酸盐被释放并氧化为硝酸盐，然后通过尿液排出，占注射量的57%。注射EGDN或EGMN会导致血压下降持续数小时，EGDN的效果更明显。由于同时测定了血压以及血液中EGDN及其代谢产物的浓度，因此尝试建立血压与血液浓度之间的相关性。有人认为，注射EGDN后血压下降可能是EGDN、EGMN和亚硝酸盐共同作用的结果。最初的血压下降可能是由于完整的EGDN分子，随后依次是EGDN分子分解过程中释放的亚硝酸盐和EGMN的作用。
