大鼠反复给药后乙二醇二硝酸酯（二硝酸乙烯酯）的代谢
Metabolism of ethylene glycol dinitrate (ethylene dinitrate) in the rat following repeated administration.
作者信息
Clark D G, Litchfield M H
出版信息
Br J Ind Med. 1969 Apr;26(2):150-5. doi: 10.1136/oem.26.2.150.
150-155. The metabolism of ethylene glycol dinitrate (EGDN) following repeated administration in the rat, and the metabolism of EDGN and nitroglycerine following repeated administration in the rat and the dog have been studied. No changes were detected in the or metabolism after repeated injection, and the pattern of excretion of EGDN metabolites in the urine did not alter. It is suggested that the tolerance that develops to the cardiovascular effects of these compounds may be due to the changing influence of some physiological compensatory mechanisms rather than to any change in the pattern of metabolism.
150 - 155. 研究了大鼠反复给药后乙二醇二硝酸酯（EGDN）的代谢，以及大鼠和犬反复给药后EGDN和硝酸甘油的代谢。反复注射后，未检测到代谢或代谢有变化，尿液中EGDN代谢物的排泄模式也未改变。有人认为，对这些化合物心血管作用产生的耐受性可能是由于某些生理代偿机制的影响发生了变化，而不是代谢模式有任何改变。
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