Sterling G M
Thorax. 1967 Nov;22(6):533-7. doi: 10.1136/thx.22.6.533.
Two patients have been studied who complained of dyspnoea after the inhalation of fumes from a new soldering flux recently developed for use in jointing aluminium which has been replacing copper as a material for electric cables. A previous survey of respiratory complaints after the use of this particular flux had failed to show any objective change in lung function, and the present cases are the first to be reported. Both subjects have been investigated by means of serial spirometry, peak flow rates, and body plethysmography following inhalation of small amounts of flux fumes; delayed and prolonged bronchoconstriction has been demonstrated. Similar results have been obtained after the inhalation of one of the main constituents of the flux, namely amino-ethyl ethanolamine, which is presumably the active allergic agent. The bronchial response is unusual in being delayed in onset but otherwise resembles pollen-sensitivity asthma rather than the infiltrative process seen in farmer's lung. The type of immune mechanism involved is speculative, but it is possible that some alteration of the amino-ethyl ethanolamine is needed before it can react with reaginic antibody fixed in the bronchial tissues.
对两名患者进行了研究，他们在吸入一种新开发的用于铝焊接的助焊剂产生的烟雾后出现呼吸困难。这种助焊剂最近开始用于铝的焊接，铝作为电缆材料正在取代铜。此前对使用这种特定助焊剂后呼吸系统疾病的调查未能显示肺功能有任何客观变化，而目前这两例是首次报告。两名受试者均通过在吸入少量助焊剂烟雾后进行系列肺活量测定、峰值流速测定和人体体积描记法进行了检查；结果显示存在延迟和持续的支气管收缩。吸入助焊剂的一种主要成分，即氨基乙基乙醇胺后也得到了类似结果，氨基乙基乙醇胺大概是起作用的变应原。这种支气管反应的不寻常之处在于其发作延迟，但在其他方面类似于花粉敏感性哮喘，而非农民肺中所见的浸润性过程。所涉及的免疫机制类型尚属推测，但有可能在氨基乙基乙醇胺能够与固定在支气管组织中的反应素抗体发生反应之前，需要对其进行某种改变。
