Lob M, Boillat M A
Schweiz Med Wochenschr. 1981 Jan 31;111(5):150-4.
While asthma on toluene diisocyanate (TDI) is well known, asthma on diphenylmethane diisocyanate (MDI) has been less frequently described. Following publication of a case in 1972 another is described which was observed in a similar situation (welding of polyurethane belts) and for which the diagnosis remained obscure for some time. A questionnaire sent to factories using this type of belt revealed two other cases of asthma on MDI. A fifth case is described in which provocative testing induced severe cardiovascular disturbances within a few hours after inhalation. Following a short review of the literature, the four new cases mentioned above are presented together with spirometric studies (provocative testing) and immunological investigations.
虽然甲苯二异氰酸酯（TDI）引发的哮喘广为人知，但二苯基甲烷二异氰酸酯（MDI）引发的哮喘较少被描述。1972年发表了一例病例后，又描述了另一例在类似情况下（聚氨酯带焊接）观察到的病例，该病例的诊断在一段时间内仍不明确。向使用这种类型皮带的工厂发送的一份调查问卷显示，还有另外两例MDI引发的哮喘病例。描述了第五例病例，其中激发试验在吸入后数小时内诱发了严重的心血管紊乱。在对文献进行简短回顾后，呈现了上述四例新病例以及肺量计研究（激发试验）和免疫学调查结果。
