99锝标记的磷化合物、45钙和85锶在双膦酸盐处理大鼠体内的分布。

Distribution of 99Tcm-labelled phosphorus compounds, 45Ca and 85Sr in diphosphonate-treated rats.

作者信息

Rohlin M, Larsson A, Hammarström L

出版信息

Acta Radiol Ther Phys Biol. 1977 Dec;16(6):513-24. doi: 10.3109/02841867709133973.

Abstract

A similar distribution of 99Tcm, 45Ca and 85Sr was obtained when injected in rats as 99Tcm-labelled pyrophosphate or ethylene-1-hydroxy-1,1-diphosphonate (EHDP), 45Ca-chloride and 85Sr-choloride respectively. The highest concentrations occurred in bone and teeth. In EHDP-treated rats, isotopes were accumulated at sites of ectopic calcifications in the lung, kidney and stomach wall as well as in mineralized tissues. These results indicate that 99Tcm, when administered as 99Tcm-labelled EHDP accumulates predominatly in the inorganic rather than organic tissue components.

摘要

当分别以99锝标记的焦磷酸盐或乙烯-1-羟基-1,1-二膦酸盐（EHDP）、氯化钙和氯化锶的形式注射到大鼠体内时，获得了类似的99锝、45钙和85锶分布情况。最高浓度出现在骨骼和牙齿中。在经EHDP处理的大鼠中，同位素在肺、肾和胃壁的异位钙化部位以及矿化组织中积累。这些结果表明，当以99锝标记的EHDP给药时，99锝主要在无机而非有机组织成分中积累。