Münzenberg K J
Arch Orthop Unfallchir. 1977 Dec 27;90(3):265-74. doi: 10.1007/BF00415480.
The treatment of osteogenesis imperfecta with magnesium is theoreticaly sound, but usually works in a few individuals. There are greater expectations with calcitonin, which reduces the overall osteolysis. The treatment of fractures should, whenever possible, be concervative. Internal fixation by plates is not indicated, because the plate should span from metaphysis to metyphysis, which leads to a softeming of the underlying cortex. Because of the weak bone, srews do not hold well. For operative treatment of the lower limb, the Küntscher nail is the fixation of choice, as well as for treatment of deformity by multiple fragmentation. Rapidly progressive scoliosis should be treated operatively from 9 years of age on.
用镁治疗成骨不全在理论上是合理的，但通常仅对少数个体有效。降钙素更被寄予厚望，它可减少整体骨溶解。骨折治疗应尽可能采取保守治疗。不建议使用钢板进行内固定，因为钢板应从干骺端跨越至骨骺端，这会导致下方皮质骨软化。由于骨骼脆弱，螺钉固定效果不佳。对于下肢手术治疗，Küntscher髓内钉是首选的固定方式，对于多发性骨折畸形的治疗也是如此。快速进展性脊柱侧凸应从9岁起进行手术治疗。
