Sherk H H, Cruz M, Stambaugh J
Clin Orthop Relat Res. 1977 Nov-Dec(129):251-7. doi: 10.1097/00003086-197711000-00038.
Small doses of vitamin D can probably prevent catastrophic skeletal demineralization in patients taking antiseizure medication. Moderate doses of vitamin D can reverse this degree of demineralization once it has occurred. Prophylactic vitamin D therapy was associated with a lowered incidence of seizure patients in the overall fracture census and a decrease in the number of in-hospital days for treatment of seizure patients with fractures. Vitamin D therapy should probably be used as a routine dietary supplement in all seizure patients at dosage levels of approximately 400 units daily. Much larger doses (50,000 units once or twice weekly) should be as necessary when these patients sustain fractures or other injuries.
小剂量维生素D或许能预防服用抗癫痫药物患者出现灾难性的骨骼脱矿质现象。一旦出现这种程度的脱矿质，中等剂量的维生素D可将其逆转。在总体骨折普查中，预防性维生素D治疗与癫痫患者骨折发生率降低以及骨折癫痫患者住院治疗天数减少相关。维生素D治疗或许应以每日约400单位的剂量作为所有癫痫患者的常规膳食补充剂使用。当这些患者发生骨折或其他损伤时，如有必要应使用大得多的剂量（每周一次或两次，每次50,000单位）。
