Dent C E, Gertner J M
Q J Med. 1976 Jul;45(179):411-20.
We describe three patients with fibrous dysplasia of bone in whom there was evidence of hypophosphataemic osteomalacia or rickets. Two of the patients had polyostotic fibrous dysplasia and osteomalacia. The third was a child with fibrous dysplasia of the facial and cranial bones and rickets. In all cases the manifestations of osteomalacia or rickets were controlled with large doses of vitamin D. In the child the rickets and hypophosphataemia ceased when most of the bone affected by fibrous dysplasia was surgically resected. Previously reported cases of the association between fibrous dysplasia and hypophosphataemic osteomalacia are reviewed. We suggest that these cases are analogous to the syndrome of 'tumour rickets' where hypophosphataemia appears to be due to the presence of a mesenchymal tumour and regresses when the tumour is removed.
我们描述了三名患有骨纤维发育不良且有低磷性骨软化症或佝偻病证据的患者。其中两名患者患有多骨型纤维发育不良和骨软化症。第三名是一名患有面部和颅骨纤维发育不良及佝偻病的儿童。在所有病例中，大剂量维生素D可控制骨软化症或佝偻病的表现。在该儿童中，当大部分受纤维发育不良影响的骨骼被手术切除后，佝偻病和低磷血症停止。本文回顾了先前报道的纤维发育不良与低磷性骨软化症关联的病例。我们认为这些病例类似于“肿瘤性佝偻病”综合征，其中低磷血症似乎是由于间充质肿瘤的存在，当肿瘤切除后低磷血症会消退。
