Harris M, Tso A Y, Kaba F W, Green W R, de la Cruz Z C
Ophthalmology. 1984 Oct;91(10):1154-60. doi: 10.1016/s0161-6420(84)34180-x.
Corneal endothelialization of the anterior chamber angle was observed in three cases of iris neovascularization and one case of post-contusion deformity. Scanning electron microscopy in two cases revealed a sheet composed of confluent fusiform cells forming a regular mosaic, growing in a tissue culture-like fashion, and extending over the anterior iris surface. Electron microscopy revealed an endothelial lining continuous with the corneal endothelium extending over the fibrovascular membrane which covered the anterior iris surface in the cases of iris neovascularization and partially extended over the trabecular meshwork in an eye with post-contusion deformity. These endothelial cells possess junctional complexes, apical villi, and prominent basement membrane. In addition, myoblastic differentiation with intracytoplasmic microfilaments, measuring 5 to 6 nm in diameter and often marginally located with fusiform densities, were observed. The presence of myoblastic features may play a role in the ability of corneal endothelial cells to migrate and participate in production of peripheral anterior synechia and ectropion of the iris.
在3例虹膜新生血管和1例挫伤后畸形病例中观察到前房角的角膜内皮化。2例的扫描电子显微镜检查显示，由融合的梭形细胞组成的薄片形成规则的镶嵌图案，以组织培养样方式生长，并延伸至虹膜前表面。电子显微镜检查显示，在虹膜新生血管病例中，内皮衬里与角膜内皮连续，延伸至覆盖虹膜前表面的纤维血管膜上，在1例有挫伤后畸形的眼中，部分延伸至小梁网。这些内皮细胞具有连接复合体、顶端微绒毛和明显的基底膜。此外，还观察到有成肌细胞分化，其胞质内微丝直径为5至6纳米，常位于边缘，呈梭形致密。成肌细胞特征的存在可能在角膜内皮细胞迁移以及参与周边前粘连和虹膜外翻形成的能力中发挥作用。
