Nomura T
Jpn J Ophthalmol. 1983;27(1):193-200.
The purpose of this study is to elucidate the extension of the corneal endothelium onto the iris surface, a condition which has been found in the eyes with rubeosis iridis in various ocular disorders. Histopathology of the anterior chamber angle was studied by electron microscopy in 6 eyes with neovascular glaucoma occurring in the advanced stage of diabetic retinopathy. Histopathological findings embraced extensive peripheral anterior synechiae occluding the filtration angle and fibrovascular tissue on the anterior surface of the iris. In addition, formation of a continuous layer of endothelium was observable on the surface of the iris facing the anterior chamber in the 6 eyes. The newly formed endothelium was continuous with the corneal endothelium at the pseudo-angle formed by the attachment of peripheral anterior synechiae. Two types of corneal endothelial cells were found near the pseudoangle, one type with degenerative changes and the other apparently engaged in normal metabolic activity. It may be assumed from these findings that, while the corneal endothelium undergoes degeneration, new cells of unknown origin proliferate on the posterior corneal surface to replace the disrupted corneal endothelium and extend onto the iris surface.
本研究的目的是阐明角膜内皮细胞延伸至虹膜表面的情况，这种情况在各种眼部疾病伴虹膜新生血管的眼中都有发现。通过电子显微镜对6只在糖尿病性视网膜病变晚期发生新生血管性青光眼的眼睛的前房角进行了组织病理学研究。组织病理学发现包括广泛的周边前粘连阻塞滤过角以及虹膜前表面的纤维血管组织。此外，在这6只眼中，面向前房的虹膜表面可观察到内皮细胞连续层的形成。新形成的内皮细胞在周边前粘连附着形成的假角处与角膜内皮细胞相连。在假角附近发现了两种类型的角膜内皮细胞，一种有退行性改变，另一种显然参与正常代谢活动。从这些发现可以推测，在角膜内皮细胞发生退变时，来源不明的新细胞在角膜后表面增殖，以取代受损的角膜内皮细胞并延伸至虹膜表面。
