Arnett C D, Fowler J S, Wolf A P, Logan J, MacGregor R R
Biol Psychiatry. 1984 Oct;19(10):1365-75.
An experimental strategy for external detection of specific neuroleptic receptors in living brain using positron emission transaxial tomography (PETT) and [11C]spiroperidol was applied to the mapping of brain neuroleptic receptors in the live baboon. A double injection of [11C]spiroperidol with an intervening time interval for carbon-11 decay and an intervening dose of (+)-butaclamol to block specific neuroleptic receptors produced two sets of PETT scans which were subtracted to produce a three-dimensional map of relative regional binding of neuroleptic receptors in the baboon brain. Sixty-five percent of the total radioactivity in the striatum was bound to neuroleptic receptors at 65 min after injection.
一种利用正电子发射断层扫描（PETT）和[11C]螺哌啶醇对活体大脑中特定抗精神病药物受体进行外部检测的实验策略，被应用于绘制活狒狒大脑中的抗精神病药物受体图谱。对[11C]螺哌啶醇进行两次注射，中间有碳-11衰变的时间间隔，并注射一剂（+）-布他拉莫以阻断特定的抗精神病药物受体，从而产生两组PETT扫描图像，将这两组图像相减，以生成狒狒大脑中抗精神病药物受体相对区域结合的三维图谱。注射后65分钟时，纹状体中65%的总放射性与抗精神病药物受体结合。
