Glusa E
Folia Haematol Int Mag Klin Morphol Blutforsch. 1984;111(4):575-9.
The pharmacological control of platelet functions was discussed. Besides specific receptor antagonists of aggregatory agents, drugs inhibiting the arachidonate metabolism and thus formation of thromboxane A2 proved to be inhibitors of platelet aggregation. Drugs influencing the cAMP level of platelets via activation of adenylate cyclase or inhibition of phosphodiesterase have a broad spectrum of inhibitory effects. By the combined use of inhibitors of platelet function potentiation of their effects is expected.
讨论了血小板功能的药理学控制。除了聚集剂的特异性受体拮抗剂外,抑制花生四烯酸代谢从而抑制血栓素A2形成的药物也被证明是血小板聚集的抑制剂。通过激活腺苷酸环化酶或抑制磷酸二酯酶来影响血小板cAMP水平的药物具有广泛的抑制作用。通过联合使用血小板功能抑制剂,预期会增强其效果。