Begg A C, Terry N H
Radiother Oncol. 1984 Dec;2(4):333-41. doi: 10.1016/s0167-8140(84)80076-6.
The growth rate of implanted tumours has been used as an assay for radiation injury in normal stroma. The subcutaneous tissue was irradiated in an unstimulated state and was then stimulated to produce new blood vessels by the inoculation of a syngeneic tumour 3 days after the last irradiation. Steep dose-response curves were obtained with a dose resolution of approximately 1 Gy. The time between irradiation and stimulation of the stroma by the tumour implant was shown to have no effect on tumour growth rate for times ranging from 1 h to 14 days after single doses. This functional assay of stromal damage has been used after irradiation with 1, 2, 5, 10 or 20 fractions of X-rays. Isoeffect data were well fitted by a linear-quadratic equation, for which the ratio of linear to quadratic coefficients (alpha/beta) was 6.2 +/- 0.6 Gy. This is on the high end of the range of published alpha/beta values for late reacting tissues and other stromal/vascular assays, but lower than those for all early reacting tissues. Overall treatment times ranging from 1 to 11 days were tested with the 2 and 5 fraction schedules. No effect attributable to slow repair or repopulation could be demonstrated over this period.
植入肿瘤的生长速率已被用作正常基质辐射损伤的一种检测方法。皮下组织在未受刺激状态下接受照射，然后在最后一次照射3天后接种同基因肿瘤以刺激产生新血管。获得了陡峭的剂量反应曲线，剂量分辨率约为1 Gy。单剂量照射后1小时至14天内，肿瘤植入刺激基质的时间对肿瘤生长速率无影响。这种基质损伤的功能检测已在接受1、2、5、10或20次X射线分次照射后使用。等效效应数据很好地拟合了线性二次方程，其线性与二次系数之比（α/β）为6.2±0.6 Gy。这处于已发表的晚期反应组织和其他基质/血管检测的α/β值范围的高端，但低于所有早期反应组织的值。使用2次和5次分次方案测试了1至11天的总治疗时间。在此期间未发现可归因于缓慢修复或再增殖的影响。
