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前列腺素A2对赤腹松鼠肾上腺和肾脏中核酸的增殖及刺激作用

Proliferative and stimulatory effects of PGA2 on nucleic acids in the adrenal and kidney of squirrel, Funambulus pennanti.

作者信息

Rana S V, Gupta V K

出版信息

Acta Morphol Neerl Scand. 1984 Dec;22(4):307-12.

PMID:6084402
Abstract

Effects of exogenous prostaglandin A2 (PGA2) on DNA and RNA contents of the adrenal and renal tissues have been examined histochemically. Loss of DNA from the chromatin was observed in both the tissues; however, cells of the capsular regions showed normal cytochemical reactions. Stimulated reactions for RNA in both the tissues but with topographical differences signify the elevated functional capacity. Results further prove the proliferative nature of PGA2. Irregularities in the endogenous secretion of PGA2 and other hormones thus caused, seems to be responsible for these effects.

摘要

已通过组织化学方法研究了外源性前列腺素A2(PGA2)对肾上腺和肾脏组织中DNA和RNA含量的影响。在这两种组织中均观察到染色质中DNA的丢失;然而,被膜区域的细胞显示出正常的细胞化学反应。两种组织中RNA的反应增强,但存在局部差异,这表明功能能力增强。结果进一步证明了PGA2的增殖性质。由此引起的PGA2和其他激素内源性分泌的异常似乎是这些影响的原因。

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