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组胺H2受体拮抗剂对PHA诱导的淋巴细胞增殖的影响。

The effects of histamine H2-receptor antagonists on PHA induced lymphocyte proliferation.

作者信息

Vickers M R, Milliner K J, Fallowfield C, Dracott B N

出版信息

Agents Actions. 1984 Oct;15(3-4):342-8. doi: 10.1007/BF01972356.

DOI:10.1007/BF01972356
PMID:6084413
Abstract

Histamine H2-receptor antagonists must be used with caution to define the pharmacology of histamine effects on lymphocyte mitogenesis induced by PHA, because they can enhance and/or suppress in their own right, because these effects are similar to those of histamine itself, because mitogenic doses of PHA can release significant amounts of histamine from supposedly pure mononuclear cell preparations.

摘要

必须谨慎使用组胺H2受体拮抗剂来确定组胺对PHA诱导的淋巴细胞有丝分裂作用的药理学，因为它们本身可以增强和/或抑制，因为这些作用与组胺本身的作用相似，因为有丝分裂剂量的PHA可以从假定的纯单核细胞制剂中释放大量组胺。

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引用本文的文献

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Haematological adverse effects of histamine H2-receptor antagonists.组胺H2受体拮抗剂的血液学不良反应。
Med Toxicol Adverse Drug Exp. 1988 Nov-Dec;3(6):430-48. doi: 10.1007/BF03259895.
2
Adverse reactions and interactions with H2-receptor antagonists.H2受体拮抗剂的不良反应及相互作用。
Med Toxicol. 1986 May-Jun;1(3):192-216. doi: 10.1007/BF03259837.

本文引用的文献

1
Neurochemical and neuropharmacological aspects of histamine receptors.
Neurochem Int. 1982;4(2-3):89-96. doi: 10.1016/0197-0186(82)90001-8.
2
The purification of human basophils.人嗜碱性粒细胞的纯化。
J Immunol. 1980 May;124(5):2519-21.
3
Cimetidine as an immunomodulator: chronic mucocutaneous candidiasis as a model.西咪替丁作为一种免疫调节剂：以慢性黏膜皮肤念珠菌病为模型
Ann Intern Med. 1980 Feb;92(2 Pt 1):192-5. doi: 10.7326/0003-4819-92-2-192.
4
Effect of histamine on the mitogenic response of human lymphocytes and its modification by cimetidine and levamisole.组胺对人淋巴细胞有丝分裂反应的影响及其被西咪替丁和左旋咪唑的修饰作用。
Agents Actions. 1981 Apr;11(1-2):84-8. doi: 10.1007/BF01991465.
5
Histamine suppression of lymphocyte activation.组胺对淋巴细胞激活的抑制作用。
Clin Exp Immunol. 1980 Mar;39(3):739-45.
6
Effects of simple imidazoles on human peripheral blood lymphocytes stimulated by mitogen or allogeneic cells.
J Immunopharmacol. 1980;2(2):225-43. doi: 10.3109/08923978009026399.
7
Effect of histamine agonists and antagonists on the production of murine reaginic antibodies.
Int J Immunopharmacol. 1981;3(4):349-56. doi: 10.1016/0192-0561(81)90030-8.
8
Immune restoration and/or augmentation of local xenogeneic graft versus host reaction by Cimetidine in vitro.
J Immunol. 1981 Jun;126(6):2272-4.
9
Impromidine, a potent inhibitor of histamine methyltransferase (HMT) and diamine oxidase (DAO).英普咪定，一种组胺甲基转移酶（HMT）和二胺氧化酶（DAO）的强效抑制剂。
Biochem Pharmacol. 1980 Oct 15;29(20):2897-900. doi: 10.1016/0006-2952(80)90033-7.
10
Mitogen stimulation of peripheral blood lymphocytes of duodenal ulcer patients during treatment with cimetidine or ranitidine.十二指肠溃疡患者在使用西咪替丁或雷尼替丁治疗期间外周血淋巴细胞的丝裂原刺激。
Gut. 1982 May;23(5):398-403. doi: 10.1136/gut.23.5.398.