组胺H2受体拮抗剂对PHA诱导的淋巴细胞增殖的影响。

The effects of histamine H2-receptor antagonists on PHA induced lymphocyte proliferation.

作者信息

Vickers M R, Milliner K J, Fallowfield C, Dracott B N

出版信息

Agents Actions. 1984 Oct;15(3-4):342-8. doi: 10.1007/BF01972356.

DOI:10.1007/BF01972356

Abstract

Histamine H2-receptor antagonists must be used with caution to define the pharmacology of histamine effects on lymphocyte mitogenesis induced by PHA, because they can enhance and/or suppress in their own right, because these effects are similar to those of histamine itself, because mitogenic doses of PHA can release significant amounts of histamine from supposedly pure mononuclear cell preparations.

摘要

必须谨慎使用组胺H2受体拮抗剂来确定组胺对PHA诱导的淋巴细胞有丝分裂作用的药理学，因为它们本身可以增强和/或抑制，因为这些作用与组胺本身的作用相似，因为有丝分裂剂量的PHA可以从假定的纯单核细胞制剂中释放大量组胺。

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