十二指肠溃疡患者在使用西咪替丁或雷尼替丁治疗期间外周血淋巴细胞的丝裂原刺激。
Mitogen stimulation of peripheral blood lymphocytes of duodenal ulcer patients during treatment with cimetidine or ranitidine.
作者信息
Peden N R, Robertson A J, Boyd E J, Brown R A, Gibbs J H, Potts R C, Wormsley K G, Beck J S
出版信息
Gut. 1982 May;23(5):398-403. doi: 10.1136/gut.23.5.398.
Abstract
During a double-blind randomised clinical trial of cimetidine and ranitidine in the management of duodenal ulcer, the response of patients' peripheral blood lymphocytes to optimal mitogenic stimulation in vitro has been measured. Treatment with cimetidine, but not ranitidine, was associated with a significant increase in the proportion of peripheral blood lymphocytes responding to this optimal mitogenic stimulation. We conclude that these effects of cimetidine may not be mediated at classical histamine H2-receptors.
摘要
在一项关于西咪替丁和雷尼替丁治疗十二指肠溃疡的双盲随机临床试验中，对患者外周血淋巴细胞在体外对最佳促有丝分裂刺激的反应进行了测定。西咪替丁治疗而非雷尼替丁治疗与对外周血淋巴细胞对这种最佳促有丝分裂刺激产生反应的比例显著增加相关。我们得出结论，西咪替丁的这些作用可能不是通过经典的组胺H2受体介导的。
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本文引用的文献
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