El Allaf D, Marchal C, El Allaf M, Chapelle J P, Deleixhe A, Carlier J
Arch Int Physiol Biochim. 1984 Oct;92(3):249-54. doi: 10.3109/13813458409104506.
Serum urea and creatinine concentrations were determined in 150 healthy subjects. The formula of Cockcroft and Gault was used in order to calculate creatinine clearance. Such estimation of creatinine clearance is widely used as a parameter for individualization of dosage of drugs secreted primary via the kidneys. The effects of age and sex were then assessed on serum urea, serum creatinine and on creatinine clearance.
对150名健康受试者测定了血清尿素和肌酐浓度。使用Cockcroft和Gault公式来计算肌酐清除率。这种肌酐清除率的估算方法被广泛用作主要经肾脏排泄的药物剂量个体化的一个参数。然后评估了年龄和性别对血清尿素、血清肌酐以及肌酐清除率的影响。
