Sokoll L J, Russell R M, Sadowski J A, Morrow F D
US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111.
Clin Chem. 1994 Dec;40(12):2276-81.
Age-adjusted reference ranges for creatinine clearance were determined in 279 women, ages 40-95 years, who were housed in a metabolic research unit and consumed a meat-free diet. Creatinine clearance, but not serum creatinine, declined with age by 0.63 mL/min per 1.73 m2 per year. Serum and urine creatinine concentrations, used to calculate clearances, were analyzed by a kinetic Jaffé procedure. In a subset of 100 subjects, fasting serum creatinine values averaged 8.3 +/- 5.2 (SD) mumol/L higher when measured by the kinetic Jaffé procedure than by an enzymatic method (creatinine PAP). The Cockcroft-Gault formula for estimating creatinine clearance from serum creatinine in women was validated, and the modification factor for the male equation was determined to be 0.84 (95% confidence interval 0.83-0.86) confirming the suggested 15% correction. A prediction formula derived from this population was similar in accuracy to the Cockcroft-Gault formula.
对279名年龄在40至95岁之间、居住在代谢研究单位且食用无肉饮食的女性，测定了年龄校正后的肌酐清除率参考范围。肌酐清除率随年龄下降，每年每1.73平方米下降0.63毫升/分钟，但血清肌酐水平未下降。用于计算清除率的血清和尿肌酐浓度通过动力学Jaffé法进行分析。在100名受试者的子集中，通过动力学Jaffé法测量的空腹血清肌酐值比酶法（肌酐PAP）平均高8.3±5.2（标准差）微摩尔/升。验证了用于从女性血清肌酐估算肌酐清除率的Cockcroft-Gault公式，并确定男性公式的修正因子为0.84（95%置信区间0.83-0.86），证实了建议的15%校正。从该人群得出的预测公式在准确性上与Cockcroft-Gault公式相似。
