Roman F, Della Zuana O, Lonchampt M, Saint Romas G, Duhault J
C R Seances Soc Biol Fil. 1984;178(4):372-81.
Biogenic amines in pons and striatum have been dosed in twenty-four months old Wistar male rats. Choline acetyltransferase (CAT) and acetylcholine esterase (ACHesterase) activities, [3H] choline uptake by a synaptosomal preparation, [3H] quinuclidinyl benzylate (QNB) binding to muscarinic cholinergic receptors have been determined in hippocampus. Malondialdehyde (MDA) levels in plasma, in liver and in lungs and the characteristics of the skin collagen have been evaluated. Important differences are shown in comparison with three months old of the same strain animals.
已对24月龄的雄性Wistar大鼠脑桥和纹状体中的生物胺进行给药。测定了海马体中胆碱乙酰转移酶（CAT）和乙酰胆碱酯酶（ACHesterase）的活性、突触体制剂对[3H]胆碱的摄取、[3H]喹核苄酯（QNB）与毒蕈碱胆碱能受体的结合。评估了血浆、肝脏和肺中的丙二醛（MDA）水平以及皮肤胶原蛋白的特性。与同品系3月龄动物相比，显示出重要差异。
