Forni E, Borri A M, Zadra F, Lo Monaco G, Rossi G, Bordoni P
Chir Ital. 1984 Aug;36(4):589-602.
Between november 1964 and december 1982, 102 patients were operated upon for the treatment of carcinoma thoracic esophagus. The philosophic objectives were to restore promptly the ability to swallow and to achieve a worthwhile survival period. To fulfill these requirements wide excision of the growth and immediate esophagogastrostomy were performed through a combined abdominal and right thoracic approach. In higher thoracic growths the Authors added a cervical phase. The resectability rate was 74% and the overall hospital mortality rate was 19,6%. Anastomotic leaks occurred in 10 patients (9,8%) with fatal outcome in 6. Pre- and postoperative care (particularly hyperalimentation and intensive respiratory therapy) and use of mechanical devices reduced the operative mortality rate to 8,1% between 1976 and 1982 without deaths in the last 16 patients. Very satisfactory palliation was achieved in 80% of the patients who survived the standard esophagogastrectomy. These patients enjoyed uncomplicated oral alimentation for the remainder of their lives. Despite there has been considerable improvement in operability and resectability rates and in survival of resection as compared to past years, long term results of treatment of carcinoma of the esophagus continue to remain disappointingly low. Overall survival rate at 5 years was 10,2% in this report. The stage of the disease influenced significantly survival: curative as opposed to palliative resections demonstrated a marked difference in 5-year survival (28,2% vs 2,8%). Long-term survival of patients with carcinoma of the esophagus will probably not improve until early diagnosis is possible. Therefore esophagogastrectomy should be the treatment of choice until other forms of therapy prove superior to it both in terms of palliation and long-term survival rate.
1964年11月至1982年12月期间,102例患者接受了胸段食管癌手术治疗。治疗的理念目标是迅速恢复吞咽能力并获得有价值的生存期。为满足这些要求,通过联合腹部和右胸入路对肿瘤进行广泛切除并立即行食管胃吻合术。对于较高胸段的肿瘤,作者增加了颈部手术阶段。切除率为74%,总住院死亡率为19.6%。10例患者(9.8%)发生吻合口漏,其中6例死亡。术前和术后护理(特别是胃肠外营养和强化呼吸治疗)以及使用机械设备使1976年至1982年期间的手术死亡率降至8.1%,最后16例患者无死亡。在标准食管胃切除术后存活的患者中,80%获得了非常满意的姑息治疗效果。这些患者余生都能顺利经口进食。尽管与过去相比,手术可操作性、切除率以及切除后的生存率有了显著提高,但食管癌治疗的长期效果仍然令人失望地低。本报告中5年总生存率为10.2%。疾病分期对生存率有显著影响:根治性切除与姑息性切除相比,5年生存率有明显差异(28.2%对2.8%)。在能够实现早期诊断之前,食管癌患者的长期生存率可能不会提高。因此,在其他治疗方法在姑息治疗和长期生存率方面被证明优于食管胃切除术之前,食管胃切除术应作为首选治疗方法。