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黑腹果蝇U1小核RNA基因

Drosophila melanogaster U1 snRNA genes.

作者信息

Alonso A, Jorcano J L, Beck E, Hovemann B, Schmidt T

出版信息

J Mol Biol. 1984 Dec 25;180(4):825-36. doi: 10.1016/0022-2836(84)90259-6.

DOI:10.1016/0022-2836(84)90259-6
PMID:6084722
Abstract

We have isolated and characterized a recombinant which contains a Drosophila melanogaster U1 small nuclear RNA (snRNA) gene colinear with the published snRNA sequence. Southern hybridizations of the fly genomic DNA, using as probe a plasmid containing only the coding region of the gene, shows that the fly contains at most three or four genes and very few related sequences for the small nuclear U1 RNA. These genes were localized by in situ hybridization at different chromosomal loci and show no spatial relationship to the U2 snRNA genes.

摘要

我们已经分离并鉴定了一种重组体，它包含一个与已发表的snRNA序列共线的黑腹果蝇U1小核RNA（snRNA）基因。用仅包含该基因编码区的质粒作为探针，对果蝇基因组DNA进行Southern杂交，结果表明果蝇中最多含有三到四个该小核U1 RNA基因，且相关序列极少。这些基因通过原位杂交定位在不同的染色体位点上，并且与U2 snRNA基因没有空间关系。

相似文献

1
Drosophila melanogaster U1 snRNA genes.黑腹果蝇U1小核RNA基因
J Mol Biol. 1984 Dec 25;180(4):825-36. doi: 10.1016/0022-2836(84)90259-6.
2
A complete and a truncated U1 snRNA gene of Drosophila melanogaster are found as inverted repeats at region 82E of the polytene chromosomes.在果蝇多线染色体的82E区域发现，黑腹果蝇完整的和截短的U1小核RNA基因呈反向重复排列。
Nucleic Acids Res. 1984 Dec 11;12(23):8835-46. doi: 10.1093/nar/12.23.8835.
3
Divergence of U2 snRNA sequences in the genome of D. melanogaster.黑腹果蝇基因组中U2小核RNA序列的差异
Nucleic Acids Res. 1984 Dec 21;12(24):9543-50. doi: 10.1093/nar/12.24.9543.
4
Isolation and characterization of Drosophila melanogaster U2 small nuclear RNA genes.黑腹果蝇U2小核RNA基因的分离与特性分析。
J Mol Biol. 1983 Sep 25;169(3):691-705. doi: 10.1016/s0022-2836(83)80165-x.
5
The genes coding for 4 snRNAs of Drosophila melanogaster: localization and determination of gene numbers.果蝇4种小核RNA的编码基因：基因定位与基因数量测定
Nucleic Acids Res. 1983 Jan 11;11(1):77-90. doi: 10.1093/nar/11.1.77.
6
Xenopus laevis U1 snRNA genes: characterisation of transcriptionally active genes reveals major and minor repeated gene families.非洲爪蟾U1小核RNA基因：转录活性基因的特征揭示了主要和次要的重复基因家族。
EMBO J. 1984 May;3(5):1075-81. doi: 10.1002/j.1460-2075.1984.tb01931.x.
7
Chicken U2 and U1 RNA genes are found in very different genomic environments but have similar promoter structures.鸡的U2和U1 RNA基因存在于非常不同的基因组环境中，但具有相似的启动子结构。
Biochemistry. 1986 Apr 22;25(8):2041-7. doi: 10.1021/bi00356a031.
8
Drosophila melanogaster genes for U1 snRNA variants and their expression during development.黑腹果蝇U1小核RNA变体的基因及其在发育过程中的表达。
Nucleic Acids Res. 1990 Dec 11;18(23):6971-9. doi: 10.1093/nar/18.23.6971.
9
Abundant pseudogenes for small nuclear RNAs are dispersed in the human genome.小核RNA的大量假基因分散在人类基因组中。
Proc Natl Acad Sci U S A. 1981 Feb;78(2):810-4. doi: 10.1073/pnas.78.2.810.
10
Human genes for U2 small nuclear RNA are tandemly repeated.U2小核RNA的人类基因是串联重复的。
Mol Cell Biol. 1984 Mar;4(3):492-9. doi: 10.1128/mcb.4.3.492-499.1984.

引用本文的文献

1
Basal level transcription of the histone H1(0) gene is mediated by a 80 bp promoter fragment.
Nucleic Acids Res. 1993 Feb 25;21(4):927-34. doi: 10.1093/nar/21.4.927.
2
Analysis of a sea urchin gene cluster coding for the small nuclear U7 RNA, a rare RNA species implicated in the 3' editing of histone precursor mRNAs.对编码小核U7 RNA的海胆基因簇的分析，U7 RNA是一种罕见的RNA，与组蛋白前体mRNA的3' 端编辑有关。
Proc Natl Acad Sci U S A. 1986 May;83(10):3243-7. doi: 10.1073/pnas.83.10.3243.
3
The localization and estimated copy number of Drosophila melanogaster U1, U4, U5 and U6 snRNA genes.黑腹果蝇U1、U4、U5和U6小核RNA基因的定位及估计拷贝数。
Nucleic Acids Res. 1988 Apr 25;16(8):3582. doi: 10.1093/nar/16.8.3582.
4
In situ hybridization at the electron microscope level: localization of transcripts on ultrathin sections of Lowicryl K4M-embedded tissue using biotinylated probes and protein A-gold complexes.电子显微镜水平的原位杂交：使用生物素化探针和蛋白A-金复合物在Lowicryl K4M包埋组织的超薄切片上定位转录本。
J Cell Biol. 1986 May;102(5):1646-53. doi: 10.1083/jcb.102.5.1646.
5
A structural analysis of P. polycephalum U1 RNA at the RNA and gene levels. Are there differentially expressed U1 RNA genes in P. polycephalum? U1 RNA evolution.多头绒泡菌U1 RNA在RNA和基因水平的结构分析。多头绒泡菌中是否存在差异表达的U1 RNA基因？U1 RNA的进化。
Nucleic Acids Res. 1989 Feb 11;17(3):1019-34. doi: 10.1093/nar/17.3.1019.
6
Formation of the 3' end of U1 snRNA is directed by a conserved sequence located downstream of the coding region.U1小核RNA 3'端的形成由位于编码区下游的保守序列引导。
EMBO J. 1985 Jul;4(7):1827-37. doi: 10.1002/j.1460-2075.1985.tb03857.x.
7
The spliceosomal snRNAs of Caenorhabditis elegans.
Nucleic Acids Res. 1990 May 11;18(9):2633-42. doi: 10.1093/nar/18.9.2633.
8
Drosophila melanogaster genes for U1 snRNA variants and their expression during development.黑腹果蝇U1小核RNA变体的基因及其在发育过程中的表达。
Nucleic Acids Res. 1990 Dec 11;18(23):6971-9. doi: 10.1093/nar/18.23.6971.
9
Evidence for a relationship between the Bombyx mori middle repetitive Bm1 sequence family and U1 snRNA.家蚕中间重复序列Bm1序列家族与U1小核RNA之间关系的证据。
Genetica. 1991;84(1):31-7. doi: 10.1007/BF00123982.