免疫反应性降钙素基因相关肽与P物质共存于脊髓感觉神经元中，并在大鼠脊髓行为反应中相互作用。
Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat.
作者信息
Wiesenfeld-Hallin Z, Hökfelt T, Lundberg J M, Forssmann W G, Reinecke M, Tschopp F A, Fischer J A
出版信息
Neurosci Lett. 1984 Nov 23;52(1-2):199-204. doi: 10.1016/0304-3940(84)90374-4.
PMID:6084836
Abstract
Using immunohistochemistry evidence was obtained for the coexistence of calcitonin gene-related peptide (CGRP)- and substance P (SP)-like immunoreactivity in spinal sensory neurons. Analysis of caudally directed biting and scratching (CBS) behavior was carried out after intrathecal administration of CGRP and SP alone or in combination. Thus, SP (up to 20 micrograms) alone caused CBS only for a few minutes after injection, whereas SP (10 micrograms) plus CGRP (20 micrograms) caused a response with a duration up to 40 min. CGRP (20 micrograms) alone had no effects in this model. These findings provide support for a possible interaction of the two peptides at synapses in the dorsal horn of the spinal cord.
摘要
利用免疫组织化学方法，在脊髓感觉神经元中获得了降钙素基因相关肽（CGRP）和P物质（SP）样免疫反应共存的证据。单独或联合鞘内注射CGRP和SP后，对尾向咬挠（CBS）行为进行了分析。因此，单独注射SP（最高20微克）仅在注射后几分钟引起CBS，而SP（10微克）加CGRP（20微克）引起的反应持续时间长达40分钟。单独注射CGRP（20微克）在该模型中无作用。这些发现为这两种肽在脊髓背角突触处可能的相互作用提供了支持。
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