Ekström J, Brodin E, Ekman R, Håkanson R, Sundler F
Regul Pept. 1984 Dec;10(1):1-10. doi: 10.1016/0167-0115(84)90047-8.
Immunoreactive vasoactive intestinal peptide (VIP) and substance P (SP) were studied in parotid, submaxillary and sublingual glands of the rat. The concentration of VIP was highest in the submaxillary gland and lowest in the parotid gland. The concentration of SP was highest in the parotid gland; it was at, or below the limit of detection in the sublingual gland. In the parotid gland the total amounts of VIP and SP were reduced by 95% after parasympathetic denervation (section of the auriculo-temporal nerve). In the submaxillary gland the total amounts of the peptides were unchanged after parasympathetic decentralization (section of the chorda-lingual nerve). In this gland the total amount of SP was reduced by 92% and that of VIP by 50%, when the chorda tympani nerve fibres were cut deep into the hilum. Cutting the nerve fibres at the hilum left the total amounts of the peptides unchanged in the submaxillary gland, whereas in the sublingual gland the total amount of VIP was reduced by 70%. Sympathetic denervation did not reduce the total amounts of the peptides. Duct ligation caused gland atrophy. In the parotid gland the total amounts of VIP and SP were reduced by 40%. In the submaxillary gland the same percentage reduction occurred with regard to SP; however, the total amount of VIP was reduced by 99%. The VIP- and SP-containing nerve fibres reach the salivary glands by the parasympathetic nerves. In both submaxillary and sublingual glands a certain fraction of VIP originates within the glands.
对大鼠腮腺、颌下腺和舌下腺中的免疫反应性血管活性肠肽（VIP）和P物质（SP）进行了研究。VIP浓度在颌下腺中最高，在腮腺中最低。SP浓度在腮腺中最高；在舌下腺中处于检测限或低于检测限。在腮腺中，副交感神经去神经支配（切断耳颞神经）后，VIP和SP的总量减少了95%。在颌下腺中，副交感神经离断（切断舌神经）后，肽类总量未发生变化。当鼓索神经纤维在腺门深处切断时，该腺体中SP总量减少了92%，VIP总量减少了50%。在腺门处切断神经纤维，颌下腺中肽类总量未变，而在舌下腺中，VIP总量减少了70%。交感神经去神经支配并未减少肽类总量。导管结扎导致腺体萎缩。在腮腺中，VIP和SP的总量减少了40%。在颌下腺中，SP也出现了相同比例的减少；然而，VIP总量减少了99%。含VIP和SP的神经纤维通过副交感神经到达唾液腺。在颌下腺和舌下腺中，一定比例的VIP起源于腺体内部。
