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关于市售抑肽酶被胰岛肽污染的问题。

On the contamination of commercially available aprotinins with pancreatic islet peptides.

作者信息

Baldissera F G, Holst J J

出版信息

Scand J Clin Lab Invest. 1984 Nov;44(7):669-72.

PMID:6085188
Abstract

Contamination of aprotinins with immunoreactive insulin, glicentin, glucagon, somatostatin, pancreatic polypeptide and pancreatic polypeptide-icosapeptide was estimated by radioimmunoassay. High somatostatin concentrations were found in two commercial preparations. Influence of somatostatin contamination of aprotinins on the clinical as well as the laboratory applications of aprotinin may thus be anticipated.

摘要

通过放射免疫分析法评估了抑肽酶中免疫反应性胰岛素、胰高血糖素样肽、胰高血糖素、生长抑素、胰多肽和胰多肽-icosapeptide的污染情况。在两种商业制剂中发现了高浓度的生长抑素。因此,可以预期抑肽酶中生长抑素污染对抑肽酶临床及实验室应用的影响。

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