Erlandsen S L
Monogr Pathol. 1980;21:140-55.
In the Lausanne classification of islet cells which is based mainly on the ultrastructural characteristics of secretion granules, a total of nine different cell types have been described. By immunocytochemistry at least 12 different hormones or peptides have been either detected or postulated as being within cell types in the pancreatic islets. The cells responsible for the secretion of insulin, glucagon, GIP, pancreatic polypeptide and somatostatin have been firmly established. The identification of cells containing VIP, secretin, gastrin, biogenic amines and other peptides still remain tentative. The development of immunocytochemical techniques and their use at the light microscopic and ultrastructural level have been of immense value in the recognition of islet cell types and the peptides that they contain. Continued improvement in the purification of islet hormones and specific antibodies to these hormones together with correlative and immunocytochemical studies should lead to a better understanding of normal islet cell function, and thus hopefully, the cellular abnormalities encountered in tumors of the endocrine pancreas.
在主要基于分泌颗粒超微结构特征的胰岛细胞洛桑分类中，共描述了9种不同的细胞类型。通过免疫细胞化学方法，已检测到或推测胰岛细胞类型中至少存在12种不同的激素或肽。分泌胰岛素、胰高血糖素、胃抑肽、胰多肽和生长抑素的细胞已得到明确证实。含有血管活性肠肽、促胰液素、胃泌素、生物胺和其他肽的细胞的鉴定仍不确定。免疫细胞化学技术的发展及其在光学显微镜和超微结构水平上的应用，对于识别胰岛细胞类型及其所含的肽具有巨大价值。胰岛激素纯化及针对这些激素的特异性抗体的持续改进，以及相关和免疫细胞化学研究，应有助于更好地理解正常胰岛细胞功能，从而有望更好地理解内分泌胰腺肿瘤中遇到的细胞异常情况。
